ArticleAAPS PharmSciTech2008
Design and evaluation of microemulsions for improved parenteral delivery of propofol.
Article in AAPS PharmSciTech, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed.
- Article
- Article
- Delineating a potent antiviral activity ofJournal of drug delivery science and technology · 2021Article
- High-Loading Self-Assembling Peptide Nanoparticles as a Lipid-Free Carrier for Hydrophobic General Anesthetics.International journal of nanomedicine · 2021Article
- Tetrahydrocurcumin-loaded vaginal nanomicrobicide for prophylaxis of HIV/AIDS: in silico study, formulation development, and in vitro evaluation.Drug delivery and translational research · 2019Article
- Enhancement of Antibacterial Activity of Orange Oil in Pectin Thin Film by Microemulsion.Nanomaterials (Basel, Switzerland) · 2018Article
- Transdermal agomelatine microemulsion gel: pyramidal screening, statistical optimization and in vivo bioavailability.Drug delivery · 2017Article
- Nanoemulsion formulations for anti-cancer agent piplartine--Characterization, toxicological, pharmacokinetics and efficacy studies.International journal of pharmaceutics · 2016Article
- Formulation of Propolis Phenolic Acids Containing Microemulsions and Their Biopharmaceutical Characterization.Evidence-based complementary and alternative medicine : eCAM · 2016Article
- Self-Microemulsifying Drug Delivery System: Formulation and Study Intestinal Permeability of Ibuprofen in Rats.Journal of pharmaceutics · 2013Article
- Thromboelastographic and pharmacokinetic profiles of micro- and macro-emulsions of propofol in swine.Biopharmaceutics & drug disposition · 2010Article
- Optimal lidocaine propofol mixture for painless induction of anesthesia.Saudi journal of anaesthesiaArticle
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The objective of this investigation was to evaluate the potential of the microemulsions to improve the parenteral delivery of propofol. Pseudo-ternary phase diagrams were plotted to identify microemulsification region of propofol. The propofol microemulsions were evaluated for globule size, physical and chemical stability, osmolarity, in vitro hemolysis, pain caused by injection using rat paw-lick test and in vivo anesthetic activity. The microemulsions exhibited globule size less than 25 nm and demonstrated good physical and chemical stability. Propofol microemulsions were slightly hypertonic and resulted in less than 1% hemolysis after 2 h of storage with human blood at 37 degrees C. Rat paw-lick test indicated that propofol microemulsions were significantly less painful as compared to the marketed propofol formulation. The anesthetic activity of the microemulsions was similar to the marketed propofol formulation indicating that they do not compromise the pharmacological action of propofol. The stability studies indicated that the microemulsions were stable for 3 months when stored at 5 +/- 3 degrees C. Thus, microemulsions appeared to be an interesting alternative to the current propofol formulations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.