ArticleEndocrine2008
Resistin is expressed in human hepatocytes and induces insulin resistance.
Article in Endocrine, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Circulatory resistin levels in inflammatory bowel disease: a systematic review and meta-analysis.BMC gastroenterology · 2024Pooled it
- Obesity and Depression.Advances in experimental medicine and biology · 2026Review
- Association of Obesity and Severe Asthma in Adults.Journal of clinical medicine · 2024Review
- Adipokines as Clinically Relevant Therapeutic Targets in Obesity.Biomedicines · 2023Review
- Non-Alcoholic Fatty Liver Disease in HIV/HBV Patients - a Metabolic Imbalance Aggravated by Antiretroviral Therapy and Perpetuated by the Hepatokine/Adipokine Axis Breakdown.Frontiers in endocrinology · 2022Review
- Cardiovascular and Metabolic Crosstalk in the Brain: Leptin and Resistin.Frontiers in physiology · 2021Review
- The Effects of Exercise on Cerebellar Growth-Associated Protein 43 and Adenylyl Cyclase- Associated Protein 1 Gene Expression and Proteins in Diabetic-Induced Neuropathy and Healthy Male Wistar Rats.International journal of preventive medicine · 2021Article
- Adipose Tissue Distribution, Inflammation and Its Metabolic Consequences, Including Diabetes and Cardiovascular Disease.Frontiers in cardiovascular medicine · 2020Review
- Maternal serum level of resistin is associated with risk for gestational diabetes mellitus: A meta-analysis.World journal of clinical cases · 2019Article
- Adipokines in Liver Cirrhosis.International journal of molecular sciences · 2017Review
- Shift work is associated with metabolic syndrome in male steel workers-the role of resistin and WBC count-related metabolic derangements.Diabetology & metabolic syndrome · 2017Article
- Association of Vitamin B12 with Pro-Inflammatory Cytokines and Biochemical Markers Related to Cardiometabolic Risk in Saudi Subjects.Nutrients · 2016Article
- Expression of miR-199a-3p in human adipocytes is regulated by free fatty acids and adipokines.Molecular medicine reports · 2016Article
- Associations of Resistin Levels with Resistin Gene Polymorphism and Metabolic Syndrome in Thais.Journal of medical biochemistry · 2015Article
- Steroid replacement in primary adrenal failure does not appear to affect circulating adipokines.Endocrine · 2015Article
- MicroRNA-492 reverses high glucose-induced insulin resistance in HUVEC cells through targeting resistin.Molecular and cellular biochemistry · 2014Article
- Signal transductions and nonalcoholic fatty liver: a mini-review.International journal of clinical and experimental medicine · 2014Review
- The mechanisms linking adiposopathy to type 2 diabetes.Frontiers of medicine · 2013Review
- Article
- Over expression of resistin in adipose tissue of the obese induces insulin resistance.World journal of diabetes · 2012Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Resistin, known as an adipocyte-specific secretory factor (ADSF), is implicated to modulate insulin resistance in rodents. However, the precise role of this factor for human insulin resistance has remained elusive. Here, we investigate the relationship between human resistin and insulin resistance in hepatocytes and the effect of Metformin on resistin. In this study, the expression of resistin in human hepatocytes and hepatic tissues was examined, and the human resistin eukaryotic expression vector was constructed and stably transfected in HepG2 cells. Data showed that resistin is expressed in human hepatocytes and hepatic tissues. Overexpression of human resistin impaired significantly insulin-stimulated glucose uptake and glycogen synthesis in HepG2 cells. It also decreased the expression of insulin receptor substrate 2 (IRS-2) and c-cbl associated protein (CAP), whereas increased the expression of glycogen synthetase kinase 3beta (GSK-3beta). The result suggested that human resistin induced insulin resistance in hepatocytes by blocking the two insulin signal transduction pathways of PI-3K/Akt and of CAP/c-cbl. We also concluded that Metformin reversed the effect of resistin and downregulated the expression of resistin in hepatocytes.
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18446452What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.