ArticleDigestive diseases and sciences2008
Kampo medicine "Dai-kenchu-to" prevents bacterial translocation in rats.
Article in Digestive diseases and sciences, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Clinical efficacy of Daikenchuto for gastrointestinal dysfunction following colon surgery: a randomized, double-blind, multicenter, placebo-controlled study (JFMC39-0902).Japanese journal of clinical oncology · 2015Trial
- Effect of TU-100, a traditional Japanese medicine, administered after hepatic resection in patients with liver cancer: a multi-center, phase III trial (JFMC40-1001).International journal of clinical oncology · 2015Trial
- The effects of the Kampo medicine (Japanese herbal medicine) "Daikenchuto" on the surgical inflammatory response following laparoscopic colorectal resection.Surgery today · 2012Trial
- Effect and Mechanism of Herbal Medicines on Cisplatin-Induced Anorexia.Pharmaceuticals (Basel, Switzerland) · 2022Review
- The inhibitory effect of TU-100 on hepatic stellate cell activation in the tumor microenvironment.Oncotarget · 2020Article
- Effect of Bacillus-direct-fed microbial on leaky gut, serum peptide YY concentration, bone mineralization, and ammonia excretion in neonatal female turkey poults fed with a rye-based diet.Poultry science · 2020Article
- No Significant Effect of Daikenchuto (TJ-100) on Peritoneal IL-9 and IFN-γ Levels After Pancreaticoduodenectomy.Clinical and experimental gastroenterology · 2020Article
- Transition of serum cytokines following pancreaticoduodenectomy: A subsidiary study of JAPAN-PD.Oncology letters · 2018Article
- Enhanced anastomotic healing by Daikenchuto (TJ-100) in rats.Scientific reports · 2018Article
- The novel preventive effect of Daikenchuto (TJ-100), a Japanese herbal drug, against neonatal necrotizing enterocolitis in rats.Pediatric surgery international · 2017Article
- TU-100 exerts a protective effect against bacterial translocation by maintaining the tight junction.Surgery today · 2017Article
- Efficiency of herbal medicine Dai-kenchu-to on portal blood flow in rat models.Annals of medicine and surgery (2012) · 2015Article
- Role of a Bacillus subtilis Direct-Fed Microbial on Digesta Viscosity, Bacterial Translocation, and Bone Mineralization in Turkey Poults Fed with a Rye-Based Diet.Frontiers in veterinary science · 2014Article
- Effect of Daikenchuto (TJ-100) on abdominal bloating in hepatectomized patients.World journal of gastrointestinal surgery · 2013Article
- Kampo medicines for gastrointestinal tract disorders: a review of basic science and clinical evidence and their future application.Journal of gastroenterology · 2013Review
- Epithelial transient receptor potential ankyrin 1 (TRPA1)-dependent adrenomedullin upregulates blood flow in rat small intestine.American journal of physiology. Gastrointestinal and liver physiology · 2013Article
- Feeding administration of Daikenchuto suppresses colitis induced by naive CD4+ T cell transfer into SCID mice.Digestive diseases and sciences · 2012Article
- Kampo medicine "Dai-kenchu-to" prevents CPT-11-induced small-intestinal injury in rats.Surgery today · 2012Article
- Effect of the Japanese herbal kampo medicine dai-kenchu-to on postoperative adhesive small bowel obstruction requiring long-tube decompression: a propensity score analysis.Evidence-based complementary and alternative medicine : eCAM · 2011Article
- Japanese herbal medicine in functional gastrointestinal disorders.Neurogastroenterology and motility · 2009Review
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Kampo medicine "Dai-kenchu-to" (DKT) has been used for treatment of ileus. The aim of this study was to evaluate the role of DKT on the bacterial translocation (BT) model in rats. Rats were divided into the following four groups: group 1, receiving only water, and groups 2, 3, and 4, receiving 100, 300, and 1,000 mg/kg/day of DKT. Rats were sacrificed 6 days after the beginning of the fast, and then the mesenteric lymph node was cultured. Inflammatory cytokines, intestinal integrity, and apoptosis were assessed. Incidence of BT in groups 3 (33%) and 4 (16%) was lower than in group 1 (66%). Interferon-gamma expression in groups 2, 3, and 4 was significantly lower than in group 1. Villous height and number of villus in groups 2, 3, and 4 were significantly taller and greater than in group 1. Apoptotic index in groups 2, 3, and 4 was significantly lower than in group 1. This is the first evidence that DKT prevents BT by reducing inflammatory reaction and maintaining intestinal integrity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.