Evidence map›Paper›PMID 18446422›Full record

SynthesisClinical orthopaedics and related research2008

Treatment of tendinopathy: what works, what does not, and what is on the horizon.

Brett M Andres, George A C Murrell

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Clinical orthopaedics and related research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 191 papers, 15 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
191citing papers in PubMed, 15 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

191 citing papers in PubMed, 15 syntheses or guidelines pooled it.

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  12. Injection therapies for Achilles tendinopathy.The Cochrane database of systematic reviews · 2015
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  14. ESWT for tendinopathy: technology and clinical implications.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2013
    Pooled it
  15. Treatment of patellar tendinopathy--a systematic review of randomized controlled trials.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2012
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  19. Ultrasound-guided dry needling with percutaneous paratenon decompression for chronic Achilles tendinopathy.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2016
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131 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Brett M AndresOrthopaedic Research Institute, St George Hospital, University of New South Wales, Level 2 Research and Education Building, 4-10 South Street, Kogarah, Sydney, NSW, 2217, Australia. bandres@yahoo.com
George A C Murrell

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

unlabelledTendinopathy is a broad term encompassing painful conditions occurring in and around tendons in response to overuse. Recent basic science research suggests little or no inflammation is present in these conditions. Thus, traditional treatment modalities aimed at controlling inflammation such as corticosteroid injections and nonsteroidal antiinflammatory medications (NSAIDS) may not be the most effective options. We performed a systematic review of the literature to determine the best treatment options for tendinopathy. We evaluated the effectiveness of NSAIDS, corticosteroid injections, exercise-based physical therapy, physical therapy modalities, shock wave therapy, sclerotherapy, nitric oxide patches, surgery, growth factors, and stem cell treatment. NSAIDS and corticosteroids appear to provide pain relief in the short term, but their effectiveness in the long term has not been demonstrated. We identified inconsistent results with shock wave therapy and physical therapy modalities such as ultrasound, iontophoresis and low-level laser therapy. Current data support the use of eccentric strengthening protocols, sclerotherapy, and nitric oxide patches, but larger, multicenter trials are needed to confirm the early results with these treatments. Preliminary work with growth factors and stem cells is promising, but further study is required in these fields. Surgery remains the last option due to the morbidity and inconsistent outcomes. The ideal treatment for tendinopathy remains unclear. LEVEL OF EVIDENCE: Level II, systematic review.

Indexed as

Anti-Inflammatory Agents, Non-SteroidalCombined Modality TherapyGlucocorticoidsHumansIntercellular Signaling Peptides and ProteinsNitroglycerinOrthopedic ProceduresPhysical Therapy ModalitiesSclerotherapyStem Cell TransplantationTendinopathyUltrasonic TherapyAnti-Inflammatory Agents, Non-SteroidalGlucocorticoidsIntercellular Signaling Peptides and ProteinsNitroglycerin

Identifiers

PMID18446422
PMCPMC2505250

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.