ReviewJournal of industrial microbiology & biotechnology2008
Regulatory mechanisms controlling antibiotic production in Streptomyces clavuligerus.
Review in Journal of industrial microbiology & biotechnology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 52 citations in OpenAlex.
- Rich Organic Nitrogen Impacts Clavulanic Acid Biosynthesis through the Arginine Metabolic Pathway in Streptomyces clavuligerus F613-1.Microbiology spectrum · 2023Article
- An integrative-omics analysis of an industrial clavulanic acid-overproducing Streptomyces clavuligerus.Applied microbiology and biotechnology · 2022Article
- Streptomyces clavuligerus: The Omics Era.Journal of industrial microbiology & biotechnology · 2021Article
- Genome editing reveals that pSCL4 is required for chromosome linearity inMicrobial genomics · 2021Article
- Clavulanic Acid Production byAntibiotics (Basel, Switzerland) · 2021Review
- Improved production of clavulanic acid by reverse engineering and overexpression of the regulatory genes in an industrial Streptomyces clavuligerus strain.Journal of industrial microbiology & biotechnology · 2019Article
- The two-component system CepRS regulates the cephamycin C biosynthesis in Streptomyces clavuligerus F613-1.AMB Express · 2019Article
- Comparative Transcriptome Analysis ofAntibiotics (Basel, Switzerland) · 2019Article
- The CagRS Two-Component System Regulates Clavulanic Acid Metabolism via Multiple Pathways inFrontiers in microbiology · 2019Article
- Activation of Secondary Metabolite Gene Clusters inFrontiers in microbiology · 2019Article
- Comparative Genomics and Metabolomics Analyses of Clavulanic Acid-ProducingFrontiers in microbiology · 2019Article
- Proteome-wide alterations in an industrial clavulanic acid producing strain ofSynthetic and systems biotechnology · 2017Article
- Dithiolopyrrolone natural products: isolation, synthesis and biosynthesis.Marine drugs · 2013Review
- Competition sensing: the social side of bacterial stress responses.Nature reviews. Microbiology · 2013Review
- The multifaceted roles of antibiotics and antibiotic resistance in nature.Frontiers in microbiology · 2013Article
- Biosynthesis of clavam metabolites.Journal of industrial microbiology & biotechnology · 2012Review
- The sequence of a 1.8-mb bacterial linear plasmid reveals a rich evolutionary reservoir of secondary metabolic pathways.Genome biology and evolution · 2010Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Streptomyces clavuligerus produces a large array of natural compounds with antibiotic, antitumor, beta-lactamase inhibition or inmunomodulating activities. The production of cephamycin C, clavulanic acid and other compounds with a clavam structure has been studied for many years. A network of regulatory mechanisms is present in S. clavuligerus to control the formation of different compounds by pathway-specific regulators or pleiotropic regulators. The possible existence of a gamma-butyrolactone signaling system in this streptomycete is emerging. In addition, S. clavuligerus possesses a stringent control mechanism somehow different from those previously reported in other Streptomyces species.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.