ReviewPediatric nephrology (Berlin, Germany)2008
The kidney in leptospirosis.
Review in Pediatric nephrology (Berlin, Germany), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.
- Clinical characteristics and outcomes of patients with leptospirosis complicated with acute pancreatitis: a systematic review.The Journal of international medical research · 2023Pooled it
- Leptospirosis.Nature reviews. Disease primers · 2025Review
- Design and set-up of the leptospirosis registryFrontiers in public health · 2025Article
- Exudative glomerulonephritis associated with acute leptospirosis in dogs.Veterinary pathology · 2024Article
- Weil's Disease in an HIV-Infected Patient: A Case Report and Literature Review.Diagnostics (Basel, Switzerland) · 2023Article
- Importance of KIM-1 and MCP-1 in Determining the Leptospirosis-Associated AKI: A Sri Lankan Study.BioMed research international · 2021Article
- Acute kidney injury due to Leptospira interrogans in 4 foals and use of renal replacement therapy with intermittent hemodiafiltration in 1 foal.Journal of veterinary internal medicine · 2020Article
- Infections and the kidney: a tale from the tropics.Pediatric nephrology (Berlin, Germany) · 2018Review
- Acute Kidney Injury Recognition in Low- and Middle-Income Countries.Kidney international reports · 2017Article
- Lp25 membrane protein from pathogenic Leptospira spp. is associated with rhabdomyolysis and oliguric acute kidney injury in a guinea pig model of leptospirosis.PLoS neglected tropical diseases · 2017Article
- Leptospira seropositivity as a risk factor for Mesoamerican Nephropathy.International journal of occupational and environmental health · 2017Article
- Sustained Tubulointerstitial Inflammation in Kidney with Severe Leptospirosis.Internal medicine (Tokyo, Japan) · 2017Article
- Pediatric Fulminant Leptospirosis Complicated by Pericardial Tamponade, Macrophage Activation Syndrome and Sclerosing Cholangitis.Balkan medical journal · 2016Article
- A Rare Presentation of Leptospirosis.European journal of case reports in internal medicine · 2016Article
- Low serum total nitrite and nitrate levels in severe leptospirosis.BMC infectious diseases · 2013Article
- Severe leptospirosis with multiple organ failure successfully treated by plasma exchange and high-volume hemofiltration.Case reports in nephrology · 2011Article
- Acute kidney injury in human leptospirosis: an immunohistochemical study with pathophysiological correlation.Virchows Archiv : an international journal of pathology · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Leptospirosis is a worldwide zoonosis. Typically, patients are young men, although children can be affected. In children, this disease causes mainly alterations of sensorium. Acute renal failure and jaundice (Weil's syndrome) are less common in children than in adults. The main renal histological findings are acute interstitial nephritis and acute tubular necrosis. Acute renal failure is characterized by hypokalemia and nonoliguria. Many factors are involved in its physiopathology: hypotension, hypovolemia, rhabdomyolysis, hyperbilirubinemia, and, primarily, the direct action of leptospiral proteins. Antibiotic administration (especially early administration) reduces length of hospitalization and leptospiruria. For children, even late antibiotic treatment has been shown to reduce the extent of acute renal failure and thrombocytopenia. Although the best method of dialysis is not yet established, early and intensive dialysis can decrease mortality. Mortality in patients with acute renal failure is approximately 15-20% in association with the presence of oliguria, higher levels of creatinine, and older age. Functional recovery is fast and complete; however, abnormal urinary concentration can persist.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.