ArticlePediatric nephrology (Berlin, Germany)2008
Oral-ibuprofen-induced acute renal failure in a preterm infant.
Article in Pediatric nephrology (Berlin, Germany), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 45 citations in OpenAlex.
- Drug-Related Side Effects and Contributing Risk Factors in Children With Congenital Heart Disease: A Cross-Sectional Study.Health science reports · 2025Article
- Case of iatrogenic neonatal acute kidney injury requiring dialysis and review of literature.BMJ case reports · 2022Article
- Predictors of successful patent ductus arteriosus closure with acetaminophen in preterm infants.Journal of perinatology : official journal of the California Perinatal Association · 2021Article
- Anti-Inflammatory Therapies for Treatment of Inflammation-Related Preterm Brain Injury.International journal of molecular sciences · 2021Review
- Efficacy and Safety of Oral Paracetamol vs. Oral Ibuprofen in the Treatment of Symptomatic Patent Ductus Arteriosus in Premature Infants.Paediatric drugs · 2019Article
- Non-dialytic management of acute kidney injury in newborns.Journal of renal injury prevention · 2017Review
- Oral paracetamol versus oral ibuprofen for closure of haemodynamically significant patent ductus arteriosus in preterm neonates (<32 weeks): a blinded, randomised, active-controlled, non-inferiority trial.BMJ paediatrics open · 2017Article
- Pharmacological Closure of Patent Ductus Arteriosus: Selecting the Agent and Route of Administration.Paediatric drugs · 2016Review
- Oral medications regarding their safety and efficacy in the management of patent ductus arteriosus.World journal of clinical pediatrics · 2016Review
- Efficacy of paracetamol for the treatment of patent ductus arteriosus in preterm neonates.Italian journal of pediatrics · 2014Article
- Evidence-based use of indomethacin and ibuprofen in the neonatal intensive care unit.Clinics in perinatology · 2012Review
- Accidental and iatrogenic causes of acute kidney injury.Current opinion in pediatrics · 2011Review
- Should we definitively abandon prophylaxis for patent ductus arteriosus in preterm new-borns?Clinics (Sao Paulo, Brazil) · 2011Review
- Changes in urinary PGE2 after ibuprofen treatment in preterm infants with patent ductus arteriosus.European journal of clinical pharmacology · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The side effects of indomethacin for ductal closure in preterm neonates (e.g. increased incidence of necrotizing enterocolitis, decreased cerebral blood volume and transient renal failure) have led clinicians to seek a safer alternative. Intravenous indomethacin and ibuprofen appear to be equally effective for patent ductus arteriosus closure, but oral ibuprofen remains an experimental option with theoretical advantages yet with potential side effects. We herein report a case of transient but severe acute renal failure developing in a preterm infant in whom oral ibuprofen was used and discuss the safety of this drug in relation to its pharmacokinetics.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.