Evidence map›Paper›PMID 18446366›Full record

ArticleEuropean journal of pediatrics2009

Drug utilisation profile in the Italian paediatric population.

Antonio Clavenna, Alessandra Berti, Lucia Gualandi, Elisa Rossi, Marisa De Rosa, Maurizio Bonati

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Article in European journal of pediatrics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 1 pooled it
6.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Observational
  10. Article
  11. Article
  12. Antiepileptic drug use in Italian children over a decade.European journal of clinical pharmacology · 2017
    Article
  13. Outpatient Antibiotic Prescription.Deutsches Arzteblatt international · 2016
    Article
  14. Article
  15. Article
  16. Paediatric clinical pharmacology in the UK.Archives of disease in childhood · 2014
    Review
  17. Article
  18. Article
  19. Article
  20. Drug utilization pattern in an Omani pediatric population.Journal of basic and clinical pharmacy · 2013
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Antonio ClavennaLaboratory for Mother and Child Health, Mario Negri Institute for Pharmacological Research, via G. La Masa 19, Milan 20156, Italy. clavenna@marionegri.it
Alessandra Berti
Lucia Gualandi
Elisa Rossi
Marisa De Rosa
Maurizio Bonati
Mario Negri Institute for Pharmacological Research · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveIn order to evaluate the prescribing pattern in the Italian paediatric population, prescriptions involving 923,353 children under 14 years old and dispensed during 2006 by the retail pharmacies of 22 Italian local health units were analysed. MATERIALS AND

methodsA total of 561,237 children (61%) received at least one drug prescription. The prescription prevalence rate was highest in children 3 years of age (78%), decreased with increasing age and was higher in boys than in girls (chi(2)=655; p<<0.001). Each treated child received an average of 3.2 prescriptions and 4.8 boxes.

resultsAntibiotics and anti-asthmatics were the more prescribed therapeutic classes and represented 80% of prescriptions. Amoxicillin+clavulanic acid was the most prescribed drug (24% of the overall population; 17% of all boxes), followed by inhaled beclometasone and amoxicillin. A total of 620 different drugs were prescribed and the ten leading drugs represented 64% of the prescribed boxes. Six of the ten most prescribed drugs were the same in all age groups. Wide differences were found in the prevalence rate between the different local health units; these ranged between 50.1 and 68.4% (p<<0.001). The prescription prevalence increased in the 2000-2002 period (from 62.2 to 68.3%) and slightly decreased afterwards.

conclusionDespite some limitations, the systematic monitoring of prescriptions is a valuable tool for evaluating the appropriateness of the care.

Indexed as

AdolescentAge FactorsAmoxicillinAmoxicillin-Potassium Clavulanate CombinationAnti-Asthmatic AgentsAnti-Bacterial AgentsBeclomethasoneChildChild, PreschoolDrug UtilizationFemaleHumansInfantItalyMalePediatricsAmoxicillinAmoxicillin-Potassium Clavulanate CombinationAnti-Asthmatic AgentsAnti-Bacterial AgentsBeclomethasonePrescription Drugs

Identifiers

PMID18446366
OpenAlexW2014477150

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.