ArticleInternational journal of hematology2008
Risk of malignant lymphoma following viral hepatitis infection.
Article in International journal of hematology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 29 citations in OpenAlex.
- Antibodies as biomarkers for cancer risk: a systematic review.Clinical and experimental immunology · 2022Pooled it
- Association between infection of hepatitis B virus and onset risk of B-cell non-Hodgkin's lymphoma: a systematic review and a meta-analysis.Medical oncology (Northwood, London, England) · 2014Pooled it
- Article
- Article
- Association of risk of non-Hodgkin's lymphoma with hepatitis B virus infection: a meta-analysis.International journal of clinical and experimental medicine · 2015Article
- Three different histological subtypes of Epstein-Barr virus-negative post-transplant lymphoproliferative disorder in a patient with hepatitis C infection.International journal of hematology · 2014Article
- Hepatitis-C Infection Incidence Among the non-Hodgkin's B-cell Lymphoma Patients in the Northeast of Iran.Iranian journal of cancer prevention · 2014Article
- Correlations of hematological parameters with bone marrow findings in chronic lymphoproliferative disorders associated with hepatitis viruses.Journal of medicine and life · 2013Article
- Hepatitis B virus infection and risk of lymphoma: results of a serological analysis within the European case-control study Epilymph.Journal of cancer research and clinical oncology · 2012Article
- Pathogenetic mechanisms of hepatitis C virus-induced B-cell lymphomagenesis.Clinical & developmental immunology · 2012Review
- Hepatitis C virus-related B cell subtypes in non Hodgkin's lymphoma.World journal of hepatology · 2011Article
- Birth order and risk of non-hodgkin lymphoma--true association or bias?American journal of epidemiology · 2010Article
- Asbestos exposure and malignant lymphoma: a multicenter case-control study in Germany and Italy.International archives of occupational and environmental health · 2010Article
- Medical history and risk of lymphoma: results of a European case-control study (EPILYMPH).Journal of cancer research and clinical oncology · 2009Article
- B-cell clonality in the liver of hepatitis C virus-infected patients.World journal of gastroenterology · 2009Article
Corrections and comments
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Authors and funding
16 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We investigated lymphoma risk following hepatitis infection in a case-control study of 274 incident lymphoma cases, defined according to the WHO classification, and 336 population controls in Sardinia, Italy. Part of our study population (198 cases and 219 controls) was included in the EPILYMPH study of Hepatitis C virus (HCV) infection in relation to non-Hodgklin's lymphoma risk. Based on questionnaire information on whether and at what age a diagnosis of hepatitis was posed by a physician, systematic anti-HCV antibodies testing in cases and controls by enzyme-linked immunoassay, and HCV-RNA assessment by PCR analyses in positive samples, we investigated more in detail whether hepatitis non-C is also associated with lymphoma risk, and whether risk varies by clinical form of hepatitis (acute or chronic infection). After adjusting by age, gender, education, and area of birth whether from the study area or elsewhere in Italy, a previous generic diagnosis of hepatitis was associated with a significantly elevated lymphoma risk [odds ratio (OR) = 1.8; 95% CI 1.1, 2.8], which was equally increased for hepatitis B (OR = 1.8; 95% CI 0.9, 3.5), for HCV positive subjects overall (OR = 2.0; 95% CI 0.8, 4.8), and for hepatitis non-B non-C (OR = 1.6; 95% CI 0.7, 3.9). Once concurrent infection from other hepatitis viruses was excluded, acute or chronic hepatitis C was the only one showing a consistent risk increase in all lymphoma subtypes, but follicular lymphoma. Some indications of an excess risk of lymphoma were observed also for acute, but not chronic forms of hepatitis B and hepatitis non-B, non C. Self-limited hepatitis C did not show an association. No significant heterogeneity in the risk of major lymphoma subtype was observed. Our results confirm a role of either acute or chronic active HCV infection in lymphomagenesis. Further studies are warranted to test the hypothesis that acute infection from other hepatitis viruses might also increase lymphoma risk.
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