ArticlePloS one2008
Ionic mechanisms of endogenous bursting in CA3 hippocampal pyramidal neurons: a model study.
Article in PloS one, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 54 citations in OpenAlex.
- Dendritic interaction of timescales in afterdepolarization potentials and nonmonotonic spike-adding.Journal of computational neuroscience · 2026Article
- Evaluation of Small-Molecule Candidates as Modulators of M-Type KInternational journal of molecular sciences · 2025Review
- Primacy of vision shapes behavioral strategies and neural substrates of spatial navigation in marmoset hippocampus.Nature communications · 2024Article
- Purkinje cell models: past, present and future.Frontiers in computational neuroscience · 2024Review
- Ion-channel degeneracy and heterogeneities in the emergence of complex spike bursts in CA3 pyramidal neurons.The Journal of physiology · 2023Article
- Emergence of stochastic resonance in a two-compartment hippocampal pyramidal neuron model.Journal of computational neuroscience · 2022Article
- Distinct burst properties contribute to the functional diversity of thalamic nuclei.The Journal of comparative neurology · 2021Article
- Regulation of Hippocampal Gamma Oscillations by Modulation of Intrinsic Neuronal Excitability.Frontiers in neural circuits · 2021Article
- Bifurcation analysis of a two-compartment hippocampal pyramidal cell model.Journal of computational neuroscience · 2016Article
- Inferring Neuronal Dynamics from Calcium Imaging Data Using Biophysical Models and Bayesian Inference.PLoS computational biology · 2016Article
- The Role of Calcium Channels in Epilepsy.Cold Spring Harbor perspectives in medicine · 2016Review
- Action potential processing in a detailed Purkinje cell model reveals a critical role for axonal compartmentalization.Frontiers in cellular neuroscience · 2015Article
- Ability of naringenin, a bioflavonoid, to activate M-type potassium current in motor neuron-like cells and to increase BKCa-channel activity in HEK293T cells transfected with α-hSlo subunit.BMC neuroscience · 2014Article
- Mechanisms by which a CACNA1H mutation in epilepsy patients increases seizure susceptibility.The Journal of physiology · 2014Article
- Low dimensional model of bursting neurons.Journal of computational neuroscience · 2014Article
- Network bursting using experimentally constrained single compartment CA3 hippocampal neuron models with adaptation.Journal of computational neuroscience · 2012Article
- Computational modeling reveals dendritic origins of GABA(A)-mediated excitation in CA1 pyramidal neurons.PloS one · 2012Article
- Article
- A computational model of Purkinje fibre single cell electrophysiology: implications for the long QT syndrome.The Journal of physiology · 2010Article
- Pharmacogenetic analysis reveals a post-developmental role for Rac GTPases in Caenorhabditis elegans GABAergic neurotransmission.Genetics · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
A critical property of some neurons is burst firing, which in the hippocampus plays a primary role in reliable transmission of electrical signals. However, bursting may also contribute to synchronization of electrical activity in networks of neurons, a hallmark of epilepsy. Understanding the ionic mechanisms of bursting in a single neuron, and how mutations associated with epilepsy modify these mechanisms, is an important building block for understanding the emergent network behaviors. We present a single-compartment model of a CA3 hippocampal pyramidal neuron based on recent experimental data. We then use the model to determine the roles of primary depolarizing currents in burst generation. The single compartment model incorporates accurate representations of sodium (Na(+)) channels (Na(V)1.1) and T-type calcium (Ca(2+)) channel subtypes (Ca(V)3.1, Ca(V)3.2, and Ca(V)3.3). Our simulations predict the importance of Na(+) and T-type Ca(2+) channels in hippocampal pyramidal cell bursting and reveal the distinct contribution of each subtype to burst morphology. We also performed fast-slow analysis in a reduced comparable model, which shows that our model burst is generated as a result of the interaction of two slow variables, the T-type Ca(2+) channel activation gate and the Ca(2+)-dependent potassium (K(+)) channel activation gate. The model reproduces a range of experimentally observed phenomena including afterdepolarizing potentials, spike widening at the end of the burst, and rebound. Finally, we use the model to simulate the effects of two epilepsy-linked mutations: R1648H in Na(V)1.1 and C456S in Ca(V)3.2, both of which result in increased cellular excitability.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.