ArticlePloS one2008
Gene expression profiling of human decidual macrophages: evidence for immunosuppressive phenotype.
Article in PloS one, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 177 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
177 citing papers in PubMed, 2 syntheses or guidelines pooled it, 373 citations in OpenAlex.
- Decidual macrophages in recurrent spontaneous abortion.Frontiers in immunology · 2022Pooled it
- Current approaches and developments in transcript profiling of the human placenta.Human reproduction update · 2020Pooled it
- Inflammatory Changes after Medical Suppression of Suspected Endometriosis for Implantation Failure: Preliminary Results.International journal of molecular sciences · 2024Trial
- Changes in peripheral immune populations during pregnancy and modulation by probiotics and ω-3 fatty acids.Scientific reports · 2020Trial
- Effects of low molecular weight heparin on the polarization and cytokine profile of macrophages and T helper cells in vitro.Scientific reports · 2018Trial
- Methylome of fetal and maternal monocytes and macrophages at the feto-maternal interface.American journal of reproductive immunology (New York, N.Y. : 1989) · 2012Trial
- Multi-omics biomarkers in female fertility: from oocyte quality to endometrial receptivity and clinical translation.Biomarker research · 2026Review
- Immune cellular homeostasis and its breakdown at the maternal-fetal interface.Trends in immunology · 2026Review
- Metamorphosing macrophages promote placental fibrosis by upregulating the transcription factor STAT5A.Journal of translational medicine · 2026Article
- Trem2 negatively regulates the MTOR-PKCα axis to protect againstFrontiers in cellular and infection microbiology · 2026Article
- Large number of CD68Medical molecular morphology · 2025Article
- Deciphering the Role and Mechanism of Decidual Monocyte-Derived Macrophage Infiltration in Obstetric Antiphospholipid Syndrome at Single-Cell Resolution.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Trem2-MICAL1-P-ERK Axis in Macrophages Confers Protection AgainstPathogens (Basel, Switzerland) · 2025Article
- Toxoplasma gondii-induced adverse pregnancy outcomes: insight into the inhibitory role of Trem2 on TLR4/TRAF6/JNK signaling pathway.Parasites & vectors · 2025Article
- Regulatory KIRScience translational medicine · 2025Article
- The potential role of the αVβ3 integrin receptor in placental biology and normal and complicated pregnancies.British journal of haematology · 2025Review
- Placental malaria infection is associated with downregulation of STAT-6 and ANG-1 in decidual macrophages.Frontiers in immunology · 2025Article
- Cross one single body 49 tissues single-cell transcriptome reveals detailed macrophage heterogeneity during pig pregnancy.Frontiers in immunology · 2025Article
- The role of placenta Hofbauer cells during pregnancy and pregnancy complications.Obstetrics & gynecology science · 2025Article
- Exploring genetic associations between immune cells and hypertensive disorder of pregnancy using Mendelian randomization.BMC pregnancy and childbirth · 2024Article
117 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 5 institutions in 3 countries.
Funding
Abstract
backgroundAlthough uterine macrophages are thought to play an important regulatory role at the maternal-fetal interface, their global gene expression profile is not known. METHODOLOGY/PRINCIPAL
findingsUsing micro-array comprising approximately 14,000 genes, the gene expression pattern of human first trimester decidual CD14+ monocytes/macrophages was characterized and compared with the expression profile of the corresponding cells in blood. Some of the key findings were confirmed by real time PCR or by secreted protein. A unique gene expression pattern intrinsic of first trimester decidual CD14+ cells was demonstrated. A large number of regulated genes were functionally related to immunomodulation and tissue remodelling, corroborating polarization patterns of differentiated macrophages mainly of the alternatively activated M2 phenotype. These include known M2 markers such as CCL-18, CD209, insulin-like growth factor (IGF)-1, mannose receptor c type (MRC)-1 and fibronectin-1. Further, the selective up-regulation of triggering receptor expressed on myeloid cells (TREM)-2, alpha-2-macroglobulin (A2M) and prostaglandin D2 synthase (PGDS) provides new insights into the regulatory function of decidual macrophages in pregnancy that may have implications in pregnancy complications. CONCLUSIONS/SIGNIFICANCE: The molecular characterization of decidual macrophages presents a unique transcriptional profile replete with important components for fetal immunoprotection and provides several clues for further studies of these cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.