ReviewJournal of perinatology : official journal of the California Perinatal Association2008
Treatment of patent ductus arteriosus: indomethacin or ibuprofen?
Review in Journal of perinatology : official journal of the California Perinatal Association, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 60 citations in OpenAlex.
- [Pediatric perioperative systemic pain therapy: Austrian interdisciplinary recommendations on pediatric perioperative pain management].Schmerz (Berlin, Germany) · 2014Guideline
- Tocolytic therapy for preterm delivery: systematic review and network meta-analysis.BMJ (Clinical research ed.) · 2012Pooled it
- Evaluation ofJournal of cardiovascular development and disease · 2026Article
- An Update on Patent Ductus Arteriosus and What is Coming Next.Turkish archives of pediatrics · 2022Article
- Article
- Patent ductus arteriosus in premature infants: to treat or not to treat?Journal of perinatology : official journal of the California Perinatal Association · 2017Article
- Bedside PDA ligation in premature infants less than 28 weeks and 1000 grams.Journal of cardiothoracic surgery · 2016Article
- Medical closure of patent ductus arteriosus does not reduce mortality and development of bronchopulmonary dysplasia in preterm infants.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2014Article
- The Association between Patent Ductus Arteriosus and Perinatal Infection in A Group of Low Birth Weight Preterm Infants.Iranian journal of pediatrics · 2014Article
- An Interesting Observation of PDA Closure with Oral Paracetamol in Preterm Neonates.Journal of clinical neonatology · 2013Article
- Does treatment of patent ductus arteriosus with cyclooxygenase inhibitors affect neonatal regional tissue oxygenation?Pediatric cardiology · 2012Article
- Should we definitively abandon prophylaxis for patent ductus arteriosus in preterm new-borns?Clinics (Sao Paulo, Brazil) · 2011Review
- Safety and effectiveness of indomethacin versus ibuprofen for treatment of patent ductus arteriosus.American journal of perinatology · 2010Article
- Patent arterial duct.Orphanet journal of rare diseases · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Persistent patent ductus arteriosus (PDA) in preterm infants can result in serious hemodynamic changes causing respiratory, gastrointestinal and renal morbidities if not treated within the first week of life. The treatment options available are a conservative approach, pharmacological treatment with cyclo-oxygenase (COX) inhibitors and surgical ligation. The COX inhibitors approved for use in the United States are indomethacin and ibuprofen lysine. Both of these drugs are equally effective in closing the PDA. Subtle differences exist between these two preparations. Indomethacin has a protective effect on the incidence of intraventricular hemorrhage (IVH) but reduces the blood flow to the kidneys and the brain. Ibuprofen is less toxic but has no effect on IVH. Efficacy of pharmacological treatment is influenced by timing of initiation of therapy. Surgical treatment is the only option when pharmacological treatment fails to close the PDA in symptomatic infants. Long-term neurological and respiratory morbidities are associated with surgical ligation. This paper reviews these medical considerations in the treatment options for PDA in premature infants.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.