ArticleMolecular pharmacology2008
Novel interaction of the dopamine D2 receptor and the Ca2+ binding protein S100B: role in D2 receptor function.
Article in Molecular pharmacology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 54 citations in OpenAlex.
- Trial
- Systematic identification of p11 as a signaling modulator across the GPCRome.Science advances · 2026Article
- The calcium-binding protein S100β regulates synaptic plasticity in the visual cortex.iScience · 2026Article
- S100 Proteins in Fatty Liver Disease and Hepatocellular Carcinoma.International journal of molecular sciences · 2022Review
- Commentary on "Novel Interaction of the Dopamine D2 Receptor and the CaMolecular pharmacology · 2021Article
- Signaling-Biased and Constitutively Active Dopamine D2 Receptor Variant.ACS chemical neuroscience · 2021Article
- Evaluation of SubstitutedMolecules (Basel, Switzerland) · 2021Article
- Emerging role of S100B protein implication in Parkinson's disease pathogenesis.Cellular and molecular life sciences : CMLS · 2021Review
- Multi-Electrode Array Analysis Identifies Complex Dopamine Responses and Glucose Sensing Properties of Substantia Nigra Neurons in Mouse Brain Slices.Frontiers in synaptic neuroscience · 2021Article
- Dopamine D2 autoreceptor interactome: Targeting the receptor complex as a strategy for treatment of substance use disorder.Pharmacology & therapeutics · 2020Review
- Article
- Intra-generational protein malnutrition impairs temporal astrogenesis in rat brain.Biology open · 2017Article
- Effects of environmental enrichment on ERK1/2 phosphorylation in the rat prefrontal cortex following nicotine-induced sensitization or nicotine self-administration.The European journal of neuroscience · 2015Article
- In vitro screening of major neurotransmitter systems possibly involved in the mechanism of action of antibodies to S100 protein in released-active form.Neuropsychiatric disease and treatment · 2015Article
- Striatal Injury with 6-OHDA Transiently Increases Cerebrospinal GFAP and S100B.Neural plasticity · 2015Article
- A synergistic approach towards understanding the functional significance of dopamine receptor interactions.Journal of molecular signaling · 2013Article
- Levels of S100B are raised in female patients with schizophrenia.BMC psychiatry · 2013Article
- Functions of S100 proteins.Current molecular medicine · 2013Review
- S100 calcium binding proteins and ion channels.Frontiers in pharmacology · 2012Article
- Identification of calcium-independent and calcium-enhanced binding between S100B and the dopamine D2 receptor.Biochemistry · 2011Article
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3 authors at 1 institution in 1 country.
Funding
Abstract
S100B is a calcium-binding protein with both extracellular and intracellular regulatory activities in the mammalian brain. We have identified a novel interaction between S100B and the dopamine D(2) receptor. Our results also suggest that the binding of S100B to the dopamine D(2) receptor enhances receptor signaling. This conclusion is based on the following observations: 1) S100B and the third cytoplasmic loop of the dopamine D(2) receptor interact in a bacterial two-hybrid system and in a poly-histidine pull-down assay; 2) immunoprecipitation of the D(2) receptor also precipitates FLAG-S100B from human embryonic kidney 293 cell homogenates and endogenous S100B from rat neostriatal homogenates; 3) S100B immunoreactivity was detected in cultured neostriatal neurons expressing the D(2) receptor; 4) a putative S100B binding motif is located at residues 233 to 240 of the D(2) receptor, toward the amino terminus of the third cytoplasmic loop. D(3)-IC3, which does not bind S100B, does not contain this motif; and 5) coexpression of S100B in D(2) receptor-expressing 293 cells selectively increased D(2) receptor stimulation of extracellular signal-regulated kinases and inhibition of adenylate cyclase.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.