ArticleThe Journal of biological chemistry2008
Neogenin-mediated hemojuvelin shedding occurs after hemojuvelin traffics to the plasma membrane.
Article in The Journal of biological chemistry, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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Who cites it
21 citing papers in PubMed, 42 citations in OpenAlex.
- Iron Accumulation and Lipid Peroxidation in the Aging Retina: Implication of Ferroptosis in Age-Related Macular Degeneration.Aging and disease · 2021Review
- Neogenin Facilitates the Induction of Hepcidin Expression by Hemojuvelin in the Liver.The Journal of biological chemistry · 2016Article
- Identification of TMPRSS6 cleavage sites of hemojuvelin.Journal of cellular and molecular medicine · 2015Article
- The liver: conductor of systemic iron balance.Blood · 2014Review
- Repulsive guidance molecules (RGMs) and neogenin in bone morphogenetic protein (BMP) signaling.Molecular reproduction and development · 2013Review
- Neogenin interacts with matriptase-2 to facilitate hemojuvelin cleavage.The Journal of biological chemistry · 2012Article
- Hereditary hemochromatosis and transferrin receptor 2.Biochimica et biophysica acta · 2012Review
- The long history of iron in the Universe and in health and disease.Biochimica et biophysica acta · 2012Review
- Liver and muscle hemojuvelin are differently glycosylated.BMC biochemistry · 2011Article
- Crystal structure of a hemojuvelin-binding fragment of neogenin at 1.8Å.Journal of structural biology · 2011Article
- Matriptase-2- and proprotein convertase-cleaved forms of hemojuvelin have different roles in the down-regulation of hepcidin expression.The Journal of biological chemistry · 2010Article
- Novel tools for the evaluation of iron metabolism.Haematologica · 2010Article
- Control of systemic iron homeostasis by the hemojuvelin-hepcidin axis.Advances in nutrition (Bethesda, Md.) · 2010Article
- Hepcidin in beta-thalassemia.Annals of the New York Academy of Sciences · 2010Article
- Expression and function of iron-regulatory proteins in retina.IUBMB life · 2010Review
- Targeting the hepcidin-ferroportin axis in the diagnosis and treatment of anemias.Advances in hematology · 2010Article
- Hemojuvelin-neogenin interaction is required for bone morphogenic protein-4-induced hepcidin expression.The Journal of biological chemistry · 2009Article
- Conformational maturation and post-ER multisubunit assembly of gap junction proteins.Molecular biology of the cell · 2009Article
- Expression of iron-related genes in human brain and brain tumors.BMC neuroscience · 2009Article
- Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
HFE2 (hemochromatosis type 2 gene) is highly expressed in skeletal muscle and liver hepatocytes. Its encoded protein, hemojuvelin (HJV), is a co-receptor for the bone morphogenetic proteins 2 and 4 (BMP2 and BMP4) and enhances the BMP-induced hepcidin expression. Hepcidin is a central iron regulatory hormone predominantly secreted from hepatocytes. HJV also binds neogenin, a membrane protein widely expressed in many tissues. Neogenin is required for the processing and release of HJV from cells. The role that neogenin plays in HJV trafficking was investigated, using HepG2 cells, a human hepatoma cell line. Knockdown of endogenous neogenin markedly suppresses HJV release but has no evident effect on HJV trafficking to the plasma membrane. The addition of a soluble neogenin ectodomain to cells markedly inhibits HJV release, indicating that the HJV shedding is not processed before trafficking to the cell surface. At the plasma membrane it undergoes endocytosis in a dynamin-independent but cholesterol-dependent manner. The additional findings that HJV release is coupled to lysosomal degradation of neogenin and that cholesterol depletion by filipin blocks both HJV endocytosis and HJV release suggest that neogenin-mediated HJV release occurs after the HJV-neogenin complex is internalized from the cell surface.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.