ArticleImmunology2008
Lymphoid enhancer factor interacts with GATA-3 and controls its function in T helper type 2 cells.
Article in Immunology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 32 citations in OpenAlex.
- Accurate, sensitive, and efficient chromatin accessibility quantification at target loci using UNIChro-seq.Nature communications · 2026Article
- Refining Diagnostic Subtypes of Peripheral T-Cell Lymphoma Using a Multiparameter Approach.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2025Article
- Identification of master regulator genes controlling pathogenic CD4Scientific reports · 2024Article
- The multifaceted roles of TCF1 in innate and adaptive lymphocytes.Advances in immunology · 2024Review
- TCF-1 Is Required for CD4 T Cell Persistence Functions during AlloImmunity.International journal of molecular sciences · 2023Article
- Tcf1 and Lef1 are required for the immunosuppressive function of regulatory T cells.The Journal of experimental medicine · 2019Article
- Effects of Glycogen Synthase Kinase-3β Inhibitor TWS119 on Proliferation and Cytokine Production of TILs From Human Lung Cancer.Journal of immunotherapy (Hagerstown, Md. : 1997) · 2018Article
- Tcf1 and Lef1 transcription factors establish CD8(+) T cell identity through intrinsic HDAC activity.Nature immunology · 2016Article
- Pulmonary Epithelial Cell-Derived Cytokine TGF-β1 Is a Critical Cofactor for Enhanced Innate Lymphoid Cell Function.Immunity · 2015Article
- From inception to output, Tcf1 and Lef1 safeguard development of T cells and innate immune cells.Immunologic research · 2014Review
- Functionally distinct Gata3/Chd4 complexes coordinately establish T helper 2 (Th2) cell identity.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Wnt your brain be inflamed? Yes, it Wnt!Trends in molecular medicine · 2013Review
- Article
- STAT6-dependent and -independent mechanisms in Th2 polarization.European journal of immunology · 2012Review
- The transcription factor Sox4 is a downstream target of signaling by the cytokine TGF-β and suppresses T(H)2 differentiation.Nature immunology · 2012Article
- Inhibition of suppressive T cell factor 1 (TCF-1) isoforms in naive CD4+ T cells is mediated by IL-4/STAT6 signaling.The Journal of biological chemistry · 2011Article
- Cell-context dependent TCF/LEF expression and function: alternative tales of repression, de-repression and activation potentials.Critical reviews in eukaryotic gene expression · 2011Review
- GATA-binding protein-3 regulates T helper type 2 cytokine and ifng loci through interaction with metastasis-associated protein 2.Immunology · 2010Article
- LEF-1 negatively controls interleukin-4 expression through a proximal promoter regulatory element.The Journal of biological chemistry · 2008Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
GATA-3 is the master transcription factor for T helper 2 (Th2) cell differentiation and is critical for the expression of Th2 cytokines. Little is known, however, about the nature of the functional molecular complexes of GATA-3. We identified a high-mobility group (HMG)-box type transcription factor, lymphoid enhancer factor 1 (LEF-1), in the GATA-3 complex present in Th2 cells using a Flag-calmodulin-binding peptide (CBP)-tag based proteomics method. The interaction between GATA-3 and LEF-1 was confirmed by co-immunoprecipitation experiments using LEF-1-introduced T-cell lineage TG40 cells. The HMG-box domain of LEF-1 and two zinc finger domains of GATA-3 were found to be important for the physical association. The introduction of LEF-1 into developing Th2 cells resulted in the suppression of Th2 cytokine production. The suppression was significantly lower in the cells into which a HMG-box-deleted LEF-1 mutant was introduced. Moreover, LEF-1 inhibited the binding activity of GATA-3 to the interleukin (IL)-5 promoter. These results suggest that LEF-1 is involved in the GATA-3 complex, while also regulating the GATA-3 function, such as the induction of Th2 cytokine expression via the inhibition of the DNA-binding activity of GATA-3.
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