ArticleThe Journal of infectious diseases2008
Maternal-fetal DNA admixture is associated with intrapartum mother-to-child transmission of HIV-1 in Blantyre, Malawi.
Article in The Journal of infectious diseases, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 23 citations in OpenAlex.
- Factors influencing maternal microchimerism throughout infancy and its impact on infant T cell immunity.The Journal of clinical investigation · 2022Article
- HTLV-1 targets human placental trophoblasts in seropositive pregnant women.The Journal of clinical investigation · 2020Article
- Maternal Microchimerism Predicts Increased Infection but Decreased Disease due to Plasmodium falciparum During Early Childhood.The Journal of infectious diseases · 2017Article
- The role of cell-associated virus in mother-to-child HIV transmission.The Journal of infectious diseases · 2014Review
- A disappearing vertical infection: will hepatitis B be a forgotten disease in children?The Korean journal of internal medicine · 2014Article
- Genotypic and phenotypic heterogeneity in the U3R region of HIV type 1 subtype C.AIDS research and human retroviruses · 2014Article
- Postnatally-transmitted HIV-1 Envelope variants have similar neutralization-sensitivity and function to that of nontransmitted breast milk variants.Retrovirology · 2013Article
- Elevated cytokine and chemokine levels in the placenta are associated with in-utero HIV-1 mother-to-child transmission.AIDS (London, England) · 2012Article
- Different regions of HIV-1 subtype C env are associated with placental localization and in utero mother-to-child transmission.Journal of virology · 2011Article
- The role of transplacental microtransfusions of maternal lymphocytes in in utero HIV transmission.Journal of acquired immune deficiency syndromes (1999) · 2010Article
- Acute HIV infection among pregnant women in Malawi.Diagnostic microbiology and infectious disease · 2010Article
- Functional genetic variants in DC-SIGNR are associated with mother-to-child transmission of HIV-1.PloS one · 2009Article
- The role of transplacental microtransfusions of maternal lymphocytes in HIV transmission to newborns.AIDS (London, England) · 2008Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
Abstract
backgroundThe mechanism of mother-to-child transmission (MTCT) of HIV-1 is not well described.
methodsOf 328 HIV-infected mother-infant pairs, we identified 91 that had discordant angiotensin I-converting enzyme and glutathione S-transferase M1 alleles. Maternal alleles in cord blood were quantified with real-time polymerase chain reaction, as indicators of microtransfusions.
resultsHIV-1 infected infants had more maternal DNA in cord blood than their uninfected counterparts. Increased maternal DNA in cord blood was associated with preterm delivery, low birth weight, and maternal immunosuppression.
conclusionIntrapartum MTCT was associated with placental microtransfusions. The associations among placental microtransfusion, in-utero MTCT, maternal immunosuppression, and poor birth outcome should be further investigated.
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