ArticleMolecular carcinogenesis2008
Wild-type APC regulates caveolin-1 expression in human colon adenocarcinoma cell lines via FOXO1a and C-myc.
Article in Molecular carcinogenesis, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 29 citations in OpenAlex.
- Article
- FOXO1: Another avenue for treating digestive malignancy?Seminars in cancer biology · 2018Review
- MicroRNA-544 promotes colorectal cancer progression by targeting forkhead box O1.Oncology letters · 2018Article
- The different functions and clinical significances of caveolin-1 in human adenocarcinoma and squamous cell carcinoma.OncoTargets and therapy · 2017Review
- Caveolin-1 in the regulation of cell metabolism: a cancer perspective.Molecular cancer · 2016Review
- Characterisation of colonic dysplasia-like epithelial atypia in murine colitis.World journal of gastroenterology · 2016Article
- Myocardin Family Members Drive Formation of Caveolae.PloS one · 2015Article
- Caveolin-1 is a novel regulator of K-RAS-dependent migration in colon carcinogenesis.International journal of cancer · 2013Article
- Mitochondria-localized caveolin in adaptation to cellular stress and injury.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2012Article
- Regulation of the metabolite profile by an APC gene mutation in colorectal cancer.Cancer science · 2012Article
- Transcriptional repression of Caveolin-1 (CAV1) gene expression by GATA-6 in bladder smooth muscle hypertrophy in mice and human beings.The American journal of pathology · 2011Article
- Identification of Mom12 and Mom13, two novel modifier loci of Apc (Min) -mediated intestinal tumorigenesis.Cell cycle (Georgetown, Tex.) · 2011Article
- Expression of caveolin in trabecular meshwork cells and its possible implication in pathogenesis of primary open angle glaucoma.Molecular vision · 2011Article
- Cancer chemoprevention locks onto a new polyamine metabolic target.Cancer prevention research (Philadelphia, Pa.) · 2010Review
- Current concepts in colorectal cancer prevention.Expert review of gastroenterology & hepatology · 2009Review
- Increased PEA3/E1AF and decreased Net/Elk-3, both ETS proteins, characterize human NSCLC progression and regulate caveolin-1 transcription in Calu-1 and NCI-H23 NSCLC cell lines.Carcinogenesis · 2009Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Genetic evidence suggests that caveolin-1, an essential component of membrane caveolae, acts as a tumor promoter in some, and a tumor suppressor in other cancers. The role of caveolin-1 in colon carcinogenesis is controversial. We report here, for the first time, that caveolin-1 is transcriptionally induced in colon cancer cells in response to conditional expression of a full length adenomatous polyposis coli (APC) gene. This induction of caveolin-1 by APC is mediated by both FOXO1a, a member of the Forkhead family of transcription factor, and c-myc. The FOXO1a protein, which is increased by wild-type APC expression, induces caveolin-1 promoter-reporter activity and binds directly to a FKHR consensus binding sequence in the caveolin-1 promoter. The c-myc protein, which is reduced in the presence of wild-type APC, acts to repress caveolin-1 expression by acting at non-E-box containing elements in the caveolin-1 promoter. These data predict that caveolin-1 protein expression would be decreased early in colonic carcinogenesis, which is associated with loss of wild-type APC. Our results would be consistent with the interpretation that caveolin-1 may have tumor suppressing functions during early stages of colon carcinogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.