ArticleJournal of neurovirology2008
Furious and paralytic rabies of canine origin: neuroimaging with virological and cytokine studies.
Article in Journal of neurovirology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 62 citations in OpenAlex.
- Paralytic rabies outbreak mimicking guillain-Barré syndrome in French Amazonia.PLoS neglected tropical diseases · 2026Article
- Targeted next-generation sequencing confirms rabies in a patient with unknown exposure: a case report.Frontiers in medicine · 2026Article
- The Challenge of Lyssavirus Infections in Domestic and Other Animals: A Mix of Virological Confusion, Consternation, Chagrin, and Curiosity.Pathogens (Basel, Switzerland) · 2025Review
- The human alpha7 nicotinic acetylcholine receptor is a host target for the rabies virus glycoprotein.Frontiers in cellular and infection microbiology · 2024Article
- Review
- A One Medicine Mission for an Effective Rabies Therapy.Frontiers in veterinary science · 2022Article
- Novel role of SARM1 mediated axonal degeneration in the pathogenesis of rabies.PLoS pathogens · 2020Article
- Inhibition of MALT1 Decreases Neuroinflammation and Pathogenicity of Virulent Rabies Virus in Mice.Journal of virology · 2018Article
- Impact of caspase-1/11, -3, -7, or IL-1Cell death discovery · 2017Article
- Intracellular Spread of Rabies Virus Is Reduced in the Paralytic Form of Canine Rabies Compared to the Furious Form.PLoS neglected tropical diseases · 2016Article
- International Veterinary Epilepsy Task Force recommendations for a veterinary epilepsy-specific MRI protocol.BMC veterinary research · 2015Article
- Virology, immunology and pathology of human rabies during treatment.The Pediatric infectious disease journal · 2015Article
- Rabies virus is recognized by the NLRP3 inflammasome and activates interleukin-1β release in murine dendritic cells.Journal of virology · 2013Article
- Reduced viral burden in paralytic compared to furious canine rabies is associated with prominent inflammation at the brainstem level.BMC veterinary research · 2013Article
- Street rabies virus causes dendritic injury and F-actin depolymerization in the hippocampus.The Journal of general virology · 2013Article
- The type I interferon response bridles rabies virus infection and reduces pathogenicity.Journal of neurovirology · 2011Article
- Atypical rabies with MRI findings: clue to the diagnosis.BMJ case reports · 2011Article
- Therapeutic immune clearance of rabies virus from the CNS.Future virology · 2011Article
Corrections and comments
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Authors and funding
14 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Furious and paralytic rabies differ in clinical manifestations and survival periods. The authors studied magnetic resonance imaging (MRI) and cytokine and virus distribution in rabies-infected dogs of both clinical types. MRI examination of the brain and upper spinal cord was performed in two furious and two paralytic dogs during the early clinical stage. Rabies viral nucleoprotein RNA and 18 cytokine mRNAs at 12 different brain regions were studied. Rabies viral RNA was examined in four furious and four paralytic dogs during the early stage, and in one each during the late stage. Cytokine mRNAs were examined in two furious and two paralytic dogs during the early stage and in one each during the late stage. Larger quantities of rabies viral RNA were found in the brains of furious than in paralytic dogs. Interleukin-1beta and interferon-gamma mRNAs were found exclusively in the brains of paralytic dogs during the early stage. Abnormal hypersignal T2 changes were found at hippocampus, hypothalamus, brainstem, and spinal cord of paralytic dogs. More widespread changes of less intensity were seen in furious dog brains. During the late stage of infection, brains from furious and paralytic rabid dogs were similarly infected and there were less detectable cytokine mRNAs. These results suggest that the early stage of furious dog rabies is characterized by a moderate inflammation (as indicated by MRI lesions and brain cytokine detection) and a severe virus neuroinvasiveness. Paralytic rabies is characterized by delayed viral neuroinvasion and a more intense inflammation than furious rabies. Dogs may be a good model for study of the host inflammatory responses that may modulate rabies virus neuroinvasiveness.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.