ArticleObesity surgery2009
Regulation of bone mineral density in morbidly obese women: a cross-sectional study in two cohorts before and after bypass surgery.
Article in Obesity surgery, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 5 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 5 syntheses or guidelines pooled it, 48 citations in OpenAlex.
- Changes in bone mineral density after bariatric surgery in patients of different ages or patients with different postoperative periods: a systematic review and meta-analysis.European journal of medical research · 2022Pooled it
- Trends in insulin-like growth factor-1 levels after bariatric surgery: a systematic review and meta-analysis.International journal of obesity (2005) · 2022Pooled it
- Changes in Bone Metabolism After Sleeve Gastrectomy Versus Gastric Bypass: a Meta-Analysis.Obesity surgery · 2020Pooled it
- Clinical practice guidelines for the perioperative nutritional, metabolic, and nonsurgical support of the bariatric surgery patient--2013 update: cosponsored by American Association of Clinical Endocrinologists, The Obesity Society, and American Society for Metabolic & Bariatric Surgery.Obesity (Silver Spring, Md.) · 2013Guideline
- Clinical practice guidelines for the perioperative nutritional, metabolic, and nonsurgical support of the bariatric surgery patient--2013 update: cosponsored by American Association of Clinical Endocrinologists, the Obesity Society, and American Society for Metabolic & Bariatric Surgery.Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical EndocrinologistsGuideline
- Evaluation of bone mineral density loss in morbidly obese women after gastric bypass: 3-year follow-up.Obesity surgery · 2011Trial
- Causal inference study of plasma proteins and blood metabolites mediating the effect of obesity-related indicators on osteoporosis.Frontiers in endocrinology · 2025Article
- Trabecular Bone Score and Bone Mineral Density in Postmenopausal Women with Morbid Obesity-A Clinical Paradox.Medical sciences (Basel, Switzerland) · 2021Article
- Metabolic and Endocrine Consequences of Bariatric Surgery.Frontiers in endocrinology · 2019Review
- Long-Term Body Composition Changes in Women Following Roux-en-Y Gastric Bypass Surgery.JPEN. Journal of parenteral and enteral nutrition · 2017Article
- Changes in Hematology and Calcium Metabolism After Gastric Bypass Surgery--a 2-Year Follow-Up Study.Obesity surgery · 2015Article
- Comparative effects of gastric bypass and sleeve gastrectomy on plasma osteopontin concentrations in humans.Surgical endoscopy · 2014Article
- Bone and mineral metabolism in patients undergoing Roux-en-Y gastric bypass.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2014Review
- Risk of fracture after bariatric surgery in the United Kingdom: population based, retrospective cohort study.BMJ (Clinical research ed.) · 2012Article
- Bone mineral changes in spine and proximal femur in individual obese women after laparoscopic sleeve gastrectomy: a short-term study.Obesity surgery · 2012Article
- Examining the link between bariatric surgery, bone loss, and osteoporosis: a review of bone density studies.Obesity surgery · 2012Review
- Contribution of adipose tissue to plasma 25-hydroxyvitamin D concentrations during weight loss following gastric bypass surgery.Obesity (Silver Spring, Md.) · 2011Article
- Bone mineral density and nutritional profile in morbidly obese women.Obesity surgery · 2010Article
- Evaluation of bone disease in morbidly obese women after gastric bypass and risk factors implicated in bone loss.Obesity surgery · 2009Article
- Gastric bypass in obese rats causes bone loss, vitamin D deficiency, metabolic acidosis, and elevated peptide YY.Surgery for obesity and related diseases : official journal of the American Society for Bariatric SurgeryArticle
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe mechanisms by which increased body weight influence bone mass density (BMD) are still unknown. The aim of our study was to analyze the relationship between anthropometric and body composition variables, insulin growth factor-I (IGF-I), adiponectin and soluble tumor necrosis factor-alpha receptors (sTNFR) 1 and 2 with BMD in two cohorts of morbid obese patients, before and after bypass surgery.
methodsThe first cohort included 25 women aged 48+/-7.6 years studied before bypass surgery. The second included 41 women aged 46+/-9.2 years, 12 months after surgery. We studied anthropometric variables obtained from whole body DEXA composition analysis. Serum IGF-I, intact serum parathyroid hormone, 25-hydroxivitamin D3, plasma adiponectin concentrations, sTNFR1, sTNFR2 concentrations were measured.
resultsIn the first cohort, the BMI was 44.5+/-3.6 kg/m2, parathyroid hormone, IGF-I, and adiponectin concentrations were lower, and sTNFR1 concentrations were higher than in the second cohort. In the multiple regression analysis, BMD remained significantly associated with body fat percentage (beta -0.154, p=0.01), lean mass (beta 0.057, p=0.016) and phosphate concentration (beta 0.225, p=0.05). In the second cohort, BMI was 31+/-5.1 kg/m2. In the multiple regression analysis, BMD remained significantly associated with lean mass (beta 0.006, p=0.03).
conclusionThe inverse correlation found between body fat and BMD in the first cohort indicates morbid obesity increases the risk of osteoporosis and we found a positive correlation with lean and fat mass before bariatric surgery and with lean mass after bypass surgery.
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