Evidence map›Paper›PMID 18443762›Full record

Trial reportDiabetologia2008

Stepwise screening for diabetes identifies people with high but modifiable coronary heart disease risk. The ADDITION study.

A Sandbaek, S J Griffin, G Rutten, M Davies, R Stolk, K Khunti, K Borch-Johnsen, N J Wareham, T Lauritzen

Registry-linked trialOpen access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Diabetologia, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00237549 (The ADDITION Study. Anglo-Danish-Dutch Study of Intensive Treatment In PeOple With screeN Detected Diabetes in Primary Care), which is not on this map. Cited by 36 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 2 pooled it
7.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00237549 nacompletednot on this map

The ADDITION Study. Anglo-Danish-Dutch Study of Intensive Treatment In PeOple With screeN Detected Diabetes in Primary Care

TypeinterventionalSponsorUniversity of AarhusRan2001 to 2009Enrolled3,057ConditionsType 2 DiabetesArmsoptimised treatment
3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 2 syntheses or guidelines pooled it, 98 citations in OpenAlex.

  1. Screening for type 2 diabetes mellitus.The Cochrane database of systematic reviews · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 3 countries.

A SandbaekDepartment of General Practice, Institute of Public Health, University of Aarhus, Aarhus, Denmark.
S J Griffin
G Rutten
M Davies
R Stolk
K Khunti
K Borch-Johnsen
N J Wareham
T Lauritzen
Aarhus University · DKAddenbrooke's Hospital · GBUniversity of Leicester · GBSteno Diabetes Center · DKUniversity Medical Center Groningen · NLUniversity Medical Center Utrecht · NL

Funding

Department of Health RP-PG-0606-1259Medical Research Council G0001164Medical Research Council MC_U106179471Medical Research Council MC_U106179474Wellcome Trust
6 · The paper itself

Abstract

aims/hypothesisThe Anglo-Danish-Dutch study of intensive treatment in people with screen-detected diabetes in primary care (ADDITION) is a pragmatic randomised controlled trial of the effectiveness of intensified multi-factorial treatment on 5 year cardiovascular morbidity and mortality rates in people with screen-detected type 2 diabetes in the Netherlands, UK and Denmark. This paper describes the baseline characteristics of the study population, their estimated risk of coronary heart disease and the extent to which that risk is potentially modifiable.

methodsStepwise screening strategies were performed using risk questionnaires and routine general practice data plus random blood glucose, HbA(1c) and fasting blood glucose measurement. Diabetes was diagnosed using the 1999 World Health Organization criteria and estimated 10 year coronary heart disease risk was calculated using the UK Prospective Diabetes Study risk engine.

resultsBetween April 2001 and December 2006, 3,057 people with screen-detected diabetes were recruited to the study (mean age 59.7 years, 58% men) after a stepwise screening programme involving 76,308 people screened in 334 general practices in three countries. Their median estimated 10 year risk of coronary heart disease was 11% in women (interquartile range 7-16%) and 21% (15-30%) in men. There were differences in the distribution of risk factors by country, linked to differences in approaches to screening and the extent to which risk factors had already been detected and treated. The mean HbA(1c) at recruitment was 7.0% (SD 1.6%). Of the people recruited, 73% had a blood pressure > or =140/90 and of these 58% were not on antihypertensive medication. Cholesterol levels were above 5.0 mmol/l in 70% of participants, 91% of whom were not being treated with lipid-lowering drugs. CONCLUSIONS/

interpretationPeople with type 2 diabetes detected by screening and included in the ADDITION study have a raised and potentially modifiable risk of CHD. ClinicalTrials.gov ID no.: NCT 00237549.

Indexed as

AdultAgedAntihypertensive AgentsCoronary DiseaseDenmarkDiabetes Mellitus, Type 2DyslipidemiasFemaleHumansHypertensionHypolipidemic AgentsMaleMass ScreeningMiddle AgedNetherlandsPlatelet Aggregation InhibitorsAntihypertensive AgentsHypolipidemic AgentsPlatelet Aggregation Inhibitors

Identifiers

PMID18443762
PMCPMC2440936
OpenAlexW2116372723

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.