ArticleJournal of molecular evolution2008
On the physical basis of the amino acid polar requirement.
Article in Journal of molecular evolution, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 54 citations in OpenAlex.
- The genetic code at the balance point of error and demand.PLoS computational biology · 2026Article
- RNA-binding protein transcripts reflect composition of target mRNAs.Nucleic acids research · 2026Article
- DEX: a consensus-based amino acid exchangeability measure for improved codon substitution modelling.bioRxiv : the preprint server for biology · 2026Article
- Ordering events in a developing genetic code.RNA biology · 2024Article
- The Genetic Code Assembles via Division and Fusion, Basic Cellular Events.Life (Basel, Switzerland) · 2023Article
- A crescendo of competent coding (c3) contains the Standard Genetic Code.RNA (New York, N.Y.) · 2022Article
- Widespread autogenous mRNA-protein interactions detected by CLIP-seq.Nucleic acids research · 2022Article
- Neutral evolution test of the spike protein of SARS-CoV-2 and its implications in the binding to ACE2.Scientific reports · 2021Article
- Fitting the standard genetic code into its triplet table.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Optimal Evolution of the Standard Genetic Code.Journal of molecular evolution · 2021Article
- Evolution of the Standard Genetic Code.Journal of molecular evolution · 2021Article
- Crick Wobble and Superwobble in Standard Genetic Code Evolution.Journal of molecular evolution · 2021Article
- RNA-protein interactions in an unstructured context.FEBS letters · 2018Review
- Tautomeric G•U pairs within the molecular ribosomal grip and fidelity of decoding in bacteria.Nucleic acids research · 2018Article
- mRNA/protein sequence complementarity and its determinants: The impact of affinity scales.PLoS computational biology · 2017Article
- A unified model of the standard genetic code.Royal Society open science · 2017Article
- Malleable nature of mRNA-protein compositional complementarity and its functional significance.Nucleic acids research · 2015Article
- Computational analysis of amino acids and their sidechain analogs in crowded solutions of RNA nucleobases with implications for the mRNA-protein complementarity hypothesis.Nucleic acids research · 2014Article
- On the Contribution of Protein Spatial Organization to the Physicochemical Interconnection between Proteins and Their Cognate mRNAs.Life (Basel, Switzerland) · 2014Article
- Life is translation.RNA biology · 2014Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Understanding how codons became associated with their specific amino acids is fundamental to deriving a theory for the origin of the genetic code. Carl Woese and coworkers designed a series of experiments to test associations between amino acids and nucleobases that may have played a role in establishing the genetic code. Through these experiments it was found that a property of amino acids called the polar requirement (PR) is correlated with the organization of the codon table. No other property of amino acids has been found that correlates with the codon table as well as PR, indicating that PR is uniquely related to the modern genetic code. Using molecular dynamics simulations of amino acids in solutions of water and dimethylpyridine used to experimentally measure PR, we show that variations in the partitioning between the two phases as described by radial distribution functions correlate well with the measured PRs. Partition coefficients based on probability densities of the amino acids in each phase have the linear behavior with base concentration as suggested by PR experiments.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.