ReviewThe journal of nutrition, health & aging2008
Frailty, osteoporosis and hip fracture: causes, consequences and therapeutic perspectives.
Review in The journal of nutrition, health & aging, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
64 citing papers in PubMed, 4 syntheses or guidelines pooled it, 148 citations in OpenAlex.
- Association between osteosarcopenia and frailty in older adults: a systematic review and meta-analysis.BMC geriatrics · 2026Pooled it
- Prognostic significance of frailty in older patients with hip fracture: a systematic review and meta-analysis.International orthopaedics · 2022Pooled it
- The Impact of Frailty on Adverse Outcomes in Geriatric Hip Fracture Patients: A Systematic Review and Meta-Analysis.Frontiers in public health · 2022Pooled it
- Depression and frailty in later life: a systematic review.Clinical interventions in aging · 2015Pooled it
- Efficacy of a single preoperative low-dose dexamethasone on 1-year mortality in geriatric femoral intertrochanteric fracture patients after internal fixation surgery: A randomized, placebo-controlled clinical trial.Chinese medical journal · 2026Trial
- A pilot randomized controlled trial to improve geriatric frailty.BMC geriatrics · 2012Trial
- Impact of Early Surgery on Clinical Outcomes of Super-Aged Patients With Hip Fractures: A Retrospective Propensity Score-Matched Study With 2-Year Follow-Up.Orthopaedic surgery · 2026Article
- Association of frailty with fragility fractures and all‑cause mortality in adults: evidence from the National Health and Nutrition Examination Survey.BMC musculoskeletal disorders · 2026Article
- Five-factor modified frailty index is a reliable indicator for predicting postoperative mortality in geriatric intertrochanteric fracture patients aged 80 years and older: a case-control study.BMC musculoskeletal disorders · 2026Article
- Association Between Herpes Zoster and Risk of Incident Fragility Fractures in US Veterans: A Matched Cohort Study.Journal of the American Geriatrics Society · 2025Article
- Construction and validation of an oral frailty risk prediction model for community-dwelling older adults.BMC geriatrics · 2025Article
- Hip Fracture as a Systemic Disease in Older Adults: A Narrative Review on Multisystem Implications and Management.Medical sciences (Basel, Switzerland) · 2025Review
- Impact of frailty and prevalent fractures on the long-term prognosis of patients with cirrhosis: a retrospective study.Scientific reports · 2025Article
- Article
- Impact of Chronic Obstructive Pulmonary Disease on Mortality Rates After Hip Pertrochanteric Fracture: A Nationwide Population-Based Cohort Study.International journal of chronic obstructive pulmonary disease · 2025Article
- Article
- Physical frailty and oral health as risk factors for low bone density in community-dwelling residents.Scientific reports · 2024Article
- The association between osteoporosis and frailty: a cross-sectional observational study and mendelian randomization analysis.Journal of orthopaedic surgery and research · 2024Observational
- Clinical Audit to Assess Orthogeriatrician Input to the Management of Elderly Trauma Patients.Cureus · 2024Article
- Frailty phenotype as mediator between systemic inflammation and osteoporosis and fracture risks: A prospective study.Journal of cachexia, sarcopenia and muscle · 2024Article
4 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors at 15 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe aim of this review of the literature is to report the factors which both contribute to the frailty syndrome and increase hip fracture risk in the elderly. This work is the fruit of common reflection by geriatricians, endocrinologists, gynecologists and rheumatologists, and seeks to stress the importance of detection and management of the various components of frailty in elderly subjects who are followed and treated for osteoporosis. It also sets out to heighten awareness of the need for management of osteoporosis in the frail elderly.
designThe current literature on frailty and its links with hip fracture was reviewed and discussed by the group.
resultsThe factors and mechanisms which are common to both osteoporosis and frailty (falls, weight loss, sarcopenia, low physical activity, cognitive decline, depression, hormones such as testosterone, estrogens, insulin-like growth factor-I (IGF-I), growth hormone (GH), vitamin D and pro-inflammatory cytokines) were identified. The obstacles to access to diagnosis and treatment of osteoporosis in the frail elderly population and common therapeutic pathways for osteoporosis and frailty were discussed.
conclusionFuture research including frail subjects would improve our understanding of how management of frailty can can contribute to lower the incidence of fractures. In parallel, more systematic management of osteoporosis should reduce the risk of becoming frail in the elderly population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.