ArticleNephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association2008
A genome-wide search for linkage to chronic kidney disease in a community-based sample: the SAFHS.
Article in Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.
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Who cites it
25 citing papers in PubMed, 3 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- Association between the ENPP1 K121Q polymorphism and risk of diabetic kidney disease: a systematic review and meta-analysis.PloS one · 2015Pooled it
- Meta-analysis of genome-wide linkage scans for renal function traits.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2012Pooled it
- A meta-analysis of genome-wide data from five European isolates reveals an association of COL22A1, SYT1, and GABRR2 with serum creatinine level.BMC medical genetics · 2010Pooled it
- Elevated serum albumin-to-creatinine ratio as a protective factor on outcomes after heart transplantation.Frontiers in cardiovascular medicine · 2023Article
- Identification of Important Modules and Hub Gene in Chronic Kidney Disease Based on WGCNA.Journal of immunology research · 2022Article
- Genomic approaches in the search for molecular biomarkers in chronic kidney disease.Journal of translational medicine · 2018Review
- Shared Genetic Factors Influence Head Motion During MRI and Body Mass Index.Cerebral cortex (New York, N.Y. : 1991) · 2017Article
- Personalized Medicine: New Perspectives for the Diagnosis and the Treatment of Renal Diseases.International journal of molecular sciences · 2017Review
- GWAS and transcriptional analysis prioritize ITPR1 and CNTN4 for a serum uric acid 3p26 QTL in Mexican Americans.BMC genomics · 2016Article
- Evaluation of neurotrophic tyrosine receptor kinase 2 (NTRK2) as a positional candidate gene for variation in estimated glomerular filtration rate (eGFR) in Mexican American participants of San Antonio Family Heart study.Journal of biomedical science · 2015Article
- Variation in genes that regulate blood pressure are associated with glomerular filtration rate in Chinese.PloS one · 2014Article
- Susceptibility gene search for nephropathy and related traits in Mexican-Americans.Molecular biology reports · 2013Review
- Plasma lipid profiling in a large population-based cohort.Journal of lipid research · 2013Article
- Genome-wide association analysis confirms and extends the association of SLC2A9 with serum uric acid levels to Mexican Americans.Frontiers in genetics · 2013Article
- Article
- Periodontitis associated with chronic kidney disease among Mexican Americans.Journal of public health dentistry · 2013Article
- Diabetic nephropathy among Mexican Americans.Clinical nephrology · 2012Review
- Increased Expression of Rififylin in A < 330 Kb Congenic Strain is Linked to Impaired Endosomal Recycling in Proximal Tubules.Frontiers in genetics · 2012Article
- FVB mouse genotype confers susceptibility to OVE26 diabetic albuminuria.American journal of physiology. Renal physiology · 2010Article
- Differences in albuminuria between Hispanics and whites: an evaluation by genetic ancestry and country of origin: the multi-ethnic study of atherosclerosis.Circulation. Cardiovascular genetics · 2010Article
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Authors and funding
10 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundChronic kidney disease (CKD) phenotypes such as albuminuria measured by urinary albumin creatinine ratio (ACR), elevated serum creatinine (SrCr) and/or decreased creatinine clearance (CrCl) and glomerular filtration rate (eGFR) are major risk factors for renal and cardiovascular diseases. Epidemiological studies have reported that CKD phenotypes cluster in families suggesting a genetic predisposition. However, studies reporting chromosomal regions influencing CKD are very limited. Therefore, the purpose of this study is to identify susceptible chromosomal regions for CKD phenotypes in Mexican American families enrolled in the San Antonio Family Heart Study (SAFHS).
methodsWe used the variance components decomposition approach (implemented in the software package SOLAR) to perform linkage analysis on 848 participants from 26 families. A total of 417 microsatellite markers were genotyped at an average interval of 10 cM spanning 22 autosomal chromosomes.
resultsAll phenotypes were measured by standard procedures. Mean +/- SD values of ACR, SrCr, CrCl and eGFR were 0.06 +/- 0.38, 0.85 +/- 0.72 mg/dl, 129.85 +/- 50.37 ml/min and 99.18 +/- 25.69 ml/min/1.73 m(2) body surface area, respectively. All four CKD phenotypes exhibited significant heritabilities (P < 0.0001). A genome-wide scan showed linkage on chromosome 2p25 for SrCr, CrCl and eGFR. Significant linkage was also detected on chromosome 9q21 for eGFR [logarithm of the odds (LOD) score = 3.87, P = 0.00005] and SrCr (LOD score = 2.6, P = 0.00026). ACR revealed suggestive evidence for linkage to a region on chromosome 20q12 (LOD score = 2.93, P = 0.00020).
conclusionFindings indicate that chromosomal regions 2p25, 9q21 and 20q12 may have functional relevance to CKD phenotypes in Mexican Americans.
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