ArticleAntimicrobial agents and chemotherapy2008
Fitness trade-offs in blaTEM evolution.
Article in Antimicrobial agents and chemotherapy, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 52 citations in OpenAlex.
- High Prevalence of Antimicrobial Resistance Genes in Rabbit Farms from Sumy Region, Ukraine.Antibiotics (Basel, Switzerland) · 2025Article
- Microbiome, resistome, and potential transfer of antibiotic resistance genes in Chinese wet market under One Health sectors.BMC microbiology · 2025Article
- Article
- Evolutionary druggability: leveraging low-dimensional fitness landscapes towards new metrics for antimicrobial applications.bioRxiv : the preprint server for biology · 2023Article
- Beyond horizontal gene transfer: the role of plasmids in bacterial evolution.Nature reviews. Microbiology · 2021Review
- Occurrence and Quantification of Antimicrobial Resistance Genes in the Gastrointestinal Microbiome of Two Wild Seabird Species With Contrasting Behaviors.Frontiers in veterinary science · 2021Article
- Escape mutations circumvent a tradeoff between resistance to a beta-lactam and resistance to a beta-lactamase inhibitor.Nature communications · 2020Article
- Multicopy plasmids allow bacteria to escape from fitness trade-offs during evolutionary innovation.Nature ecology & evolution · 2018Article
- Abundances of Clinically Relevant Antibiotic Resistance Genes and Bacterial Community Diversity in the Weihe River, China.International journal of environmental research and public health · 2018Article
- Rational design of antibiotic treatment plans: a treatment strategy for managing evolution and reversing resistance.PloS one · 2015Article
- Reversibility of antibiotic resistance.Upsala journal of medical sciences · 2014Review
- Klebsiella: a long way to go towards understanding this enigmatic jet-setter.F1000prime reports · 2014Review
- Non-phenotypic tests to detect and characterize antibiotic resistance mechanisms in Enterobacteriaceae.Diagnostic microbiology and infectious disease · 2013Review
- A design-constraint trade-off underpins the diversity in ecologically important traits in species Escherichia coli.The ISME journal · 2013Article
- Designing antibiotic cycling strategies by determining and understanding local adaptive landscapes.PloS one · 2013Article
- Expression of OXA-type and SFO-1 β-lactamases induces changes in peptidoglycan composition and affects bacterial fitness.Antimicrobial agents and chemotherapy · 2012Article
- Evolution of a single gene highlights the complexity underlying molecular descriptions of fitness.Chaos (Woodbury, N.Y.) · 2010Article
- Antimicrobial resistances do not affect colonization parameters of intestinal E. coli in a small piglet group.Gut pathogens · 2009Article
- Recombination and selection can remove blaTEM alleles from bacterial populations.Antimicrobial agents and chemotherapy · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
bla(TEM-1) expression results in penicillin resistance, whereas expression of many bla(TEM-1) descendants, called extended-spectrum beta-lactamases (ESBLs), results simultaneously in resistance to penicillins and extended-spectrum cephalosporins. Despite the expanded resistance phenotypes conferred by many ESBLs, bla(TEM-1) is still the most abundant bla(TEM) allele in many microbial populations. This study examines the fitness effects of the two amino acid substitutions, R164S and E240K, that have occurred repeatedly among ESBL bla(TEM-1) descendants. Using a single-nucleotide polymorphism-specific real-time quantitative PCR method, we analyzed the fitness of strains expressing bla(TEM-1), bla(TEM-10), and bla(TEM-12). Our results show that bacteria expressing the ancestral bla(TEM-1) allele have a fitness advantage over those expressing either bla(TEM-10) or bla(TEM-12) when exposed to ampicillin. This observation, combined with the fact that penicillins are the most prevalent antimicrobials prescribed worldwide, may explain why bla(TEM-1) has persisted as the most frequently encountered bla(TEM) allele in bacterial populations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.