ArticleAntimicrobial agents and chemotherapy2008
SGI2, a relative of Salmonella genomic island SGI1 with an independent origin.
Article in Antimicrobial agents and chemotherapy, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
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- IncFIB-4.1 and IncFIB-4.2 Single-Replicon Plasmids: Small Backbones with Large Accessory Regions.Infection and drug resistance · 2022Article
- Salmonella Genomic Island 1 requires a self-encoded small RNA for mobilization.Molecular microbiology · 2021Article
- Long-Read Sequencing Reveals Evolution and Acquisition of Antimicrobial Resistance and Virulence Genes inFrontiers in microbiology · 2021Article
- Detection of mobile genetic elements associated with antibiotic resistance in Salmonella enterica using a newly developed web tool: MobileElementFinder.The Journal of antimicrobial chemotherapy · 2021Article
- Emergence ofAntimicrobial agents and chemotherapy · 2020Article
- Identifying emerging trends in antimicrobial resistance using Salmonella surveillance data in poultry in Spain.Transboundary and emerging diseases · 2020Article
- Global phylogenomics of multidrug-resistant Salmonella enterica serotype Kentucky ST198.Microbial genomics · 2019Article
- Identification and Characterization ofFrontiers in microbiology · 2019Article
- ISFrontiers in microbiology · 2019Article
- Mobile Genetic Elements Associated with Antimicrobial Resistance.Clinical microbiology reviews · 2018Review
- Genetic Relationships among Multidrug-Resistant Salmonella enterica Serovar Typhimurium Strains from Humans and Animals.Antimicrobial agents and chemotherapy · 2018Article
- PGI2 Is a Novel SGI1-Relative Multidrug-Resistant Genomic Island Characterized in Proteus mirabilis.Antimicrobial agents and chemotherapy · 2018Article
- Identification and Characterization of New Resistance-Conferring SGI1s (Frontiers in microbiology · 2018Article
- Porcine commensal Escherichia coli: a reservoir for class 1 integrons associated with IS26.Microbial genomics · 2017Article
- pSY153-MDR, a p12969-DIM-related mega plasmid carryingOncotarget · 2017Article
- Genomic Microbial Epidemiology Is Needed to Comprehend the Global Problem of Antibiotic Resistance and to Improve Pathogen Diagnosis.Frontiers in microbiology · 2016Review
- Chromosome-mediated multidrug resistance in Salmonella enterica serovar Typhi.Antimicrobial agents and chemotherapy · 2015Article
- The extended regulatory networks of SXT/R391 integrative and conjugative elements and IncA/C conjugative plasmids.Frontiers in microbiology · 2015Review
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3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Multiply antibiotic-resistant Salmonella enterica serovar Emek strains isolated in Australia and the United Kingdom had similar features, suggesting that they all belong to a single clone. These strains all contain SGI2 (formerly SGI1-J), an independently formed relative of Salmonella genomic island SGI1. In SGI2, the complex class 1 integron which includes all of the resistance genes is not located between tnpR (S027) and S044 as in SGI1 and SGI1 variants. Instead, tnpR was found to be adjacent to S044, and the integron is located 6.9 kb away, within S023. In both SGI1 and SGI2, the 25-bp inverted repeats that mark the outer ends of class 1 integrons are flanked by a 5-bp duplication of the target, indicating that incorporation of the integron was by transposition. A small number of differences between the sequences of the backbones of SGI1 and SGI2 were also found. Hence, a class 1 integron has entered two different variants of the SGI backbone to generate two distinct lineages. Despite this, the integron in SGI2 has a complex structure that is very similar to that of In104 in SGI1. Differences are in the cassette arrays and in the gene which encodes the chloramphenicol and florfenicol efflux protein. The CmlA9 protein, encoded by InEmek, is only 92.8% identical to FloRc (also a CmlA family protein) from SGI1. A variant form of SGI2, SGI2-A, which has lost the tet(G) and cmlA9 resistance determinants, was found in one strain.
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