ArticleLipids in health and disease2008
Effects of a high fat diet on bone of growing rats. Correlations between visceral fat, adiponectin and bone mass density.
Article in Lipids in health and disease, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 58 citations in OpenAlex.
- Metabolic and Redox-Related Effects of Mauritia flexuosa (Buriti) Oil Supplementation in Wistar Rats.Journal of food science · 2026Article
- High-fat diet, intestinal microecology and bone loss.Nutrition & metabolism · 2025Review
- Chromium nanoparticles improve bone turnover regulation in rats fed a high-fat, low-fibre diet.PloS one · 2024Article
- Impact of Environmental and Epigenetic Changes on Mesenchymal Stem Cells during Aging.International journal of molecular sciences · 2023Review
- Simvastatin reverses the harmful effects of high fat diet on titanium rod osseointegration in ovariectomized rats.Journal of bone and mineral metabolism · 2021Article
- Early Nutrition during Hospitalization in Relation to Bone Health in Preterm Infants at Term Age and Six Months Corrected Age.Nutrients · 2021Article
- Programming Effect of the Parental Obesity on the Skeletal System of Offspring at Weaning Day.Animals : an open access journal from MDPI · 2021Article
- A diet high in fat and fructose adversely affects osseointegration of titanium implants in rats.Clinical and experimental dental research · 2020Article
- Vaspin antagonizes high fat-induced bone loss in rats and promotes osteoblastic differentiation in primary rat osteoblasts through Smad-Runx2 signaling pathway.Nutrition & metabolism · 2020Article
- Regulation of calcific vascular and valvular disease by nuclear receptors.Current opinion in lipidology · 2019Review
- High-fat/high-sucrose diet results in higher bone mass in aged rats.Bone reports · 2018Article
- Relationship between adiponectin and leptin on osteocalcin in obese adolescents during weight loss therapy.Archives of endocrinology and metabolism · 2018Article
- Fat, Sugar, and Bone Health: A Complex Relationship.Nutrients · 2017Review
- The effects of high-fat diet on implant osseointegration: an experimental study.Journal of the Korean Association of Oral and Maxillofacial Surgeons · 2016Article
- Article
- Propranolol, a β-adrenergic antagonist, attenuates the decrease in trabecular bone mass in high calorie diet fed growing mice.BMB reports · 2014Article
- Rats fed diets with different energy contribution from fat do not differ in adiposity.Obesity facts · 2014Article
- Maternal high fat feeding does not have long-lasting effects on body composition and bone health in female and male Wistar rat offspring at young adulthood.Molecules (Basel, Switzerland) · 2013Article
- Article
- Correlation between body mass index and orthodontic treatment outcome.The Angle orthodontist · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this study, we investigated some bone parameters (bone mineral content, bone mineral density, skeleton area) in growing rats fed with a high fat diet. Correlations between bone and body composition parameters are reported. Two groups of Wistar male rats (35 days old, body mass 80 +/- 6 g) were used. Water and food were given "ad libitum" during 10 weeks. Sixteen rats (L) were given a lipid enriched diet and were compared to 16 rats (S) fed with a standard diet. Body composition and bone parameters were assessed using DXA. Results indicated that L rats had lower body mass, lean body mass; fat mass was not different between the two groups. Bone mineral content, bone mineral density, skeleton area of L rats were lower compared with S rats. Significant correlations were noted between body composition, adiponectin and bone parameters. High fat diet intake during the growing period has deleterious effects on bone parameters in rats. This study confirms in growing rats that a high fat diet is pathogenic, including bone metabolism.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.