ArticleJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research2008
Quantitative trait loci for BMD in an SM/J by NZB/BlNJ intercross population and identification of Trps1 as a probable candidate gene.
Article in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Genetic determinants of trabecular and cortical volumetric bone mineral densities and bone microstructure.PLoS genetics · 2013Pooled it
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- Assessment of gene-by-sex interaction effect on bone mineral density.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2012Article
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- Rare coding variants in ALPL are associated with low serum alkaline phosphatase and low bone mineral density.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2012Article
- The need for mouse models in osteoporosis genetics research.BoneKEy reports · 2012Article
- Identification of quantitative trait loci influencing skeletal architecture in mice: emergence of Cdh11 as a primary candidate gene regulating femoral morphology.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2011Article
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- Mouse BMD quantitative trait loci show improved concordance with human genome-wide association loci when recalculated on a new, common mouse genetic map.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2010Article
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- Identification of the GATA factor TRPS1 as a repressor of the osteocalcin promoter.The Journal of biological chemistry · 2009Article
- A new standard genetic map for the laboratory mouse.Genetics · 2009Article
- A Cmv2 QTL on chromosome X affects MCMV resistance in New Zealand male mice.Mammalian genome : official journal of the International Mammalian Genome Society · 2009Article
- Practical applications of the bioinformatics toolbox for narrowing quantitative trait loci.Genetics · 2008Article
- QTL underlying voluntary exercise in mice: interactions with the "mini muscle" locus and sex.The Journal of heredityArticle
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
Identification of genes that regulate BMD will enhance our understanding of osteoporosis and could provide novel molecular targets for treatment or prevention. We generated a mouse intercross population and carried out a quantitative trait locus (QTL) analysis of 143 female and 124 male F(2) progeny from progenitor strains SM/J and NZB/BlNJ using whole body and vertebral areal BMD (aBMD) as measured by DXA. We found that both whole body and vertebral aBMD was affected by two loci on chromosome 9: one with a significant epistatic interaction on distal chromosome 8 and the other with a sex-specific effect. Two additional significant QTLs were identified on chromosome 12, and several suggestive ones were identified on chromosomes 5, 8, 15, and 19. The chromosome 9, 12, and 15 loci have been previously identified in other crosses. SNP-based haplotype analysis of the progenitor strains identified blocks within the QTL region that distinguish the low allele strains from the high allele strains, significantly narrowing the QTL region and reducing the possible candidate genes to 98 for chromosome 9, 31 for chromosome 12, and only 2 for chromosome 15. Trps1 is the most probable candidate gene for the chromosome 15 QTL. The sex-specific effects may help to elucidate the BMD differences between males and females. This study shows the power of statistical modeling to resolve linked QTLs and the use of haplotype analysis in narrowing the list of candidates.
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