Evidence map›Paper›PMID 18442284›Full record

ArticleJournal of proteome research2008

A computational strategy to analyze label-free temporal bottom-up proteomics data.

Xiuxia Du, Stephen J Callister, Nathan P Manes, Joshua N Adkins, Roxana A Alexandridis, Xiaohua Zeng, Jung Hyeob Roh, William E Smith, Timothy J Donohue, Samuel Kaplan and 2 more

Abstract read
In one paragraph

Article in Journal of proteome research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Proteomics: a pragmatic perspective.Nature biotechnology · 2010
    Review
  11. A glimpse into the proteome of phototrophic bacterium Rhodobacter capsulatus.Advances in experimental medicine and biology · 2010
    Article
  12. Review
  13. System estimation from metabolic time-series data.Bioinformatics (Oxford, England) · 2008
    Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Xiuxia DuFundamental and Computational Sciences Directorate, Pacific Northwest National Laboratory, Richland, Washington 99352, USA.
Stephen J Callister
Nathan P Manes
Joshua N Adkins
Roxana A Alexandridis
Xiaohua Zeng
Jung Hyeob Roh
William E Smith
Timothy J Donohue
Samuel Kaplan
Richard D Smith
Mary S Lipton

Funding

INDUCTION AND BIOGENESIS OF SUBCELLULAR ORGANELLESR01GM015590 · NIGMS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI KAPLAN, SAMUEL · 1985 to 2008
$3.0M
Bacterial Response to Singlet OxygenR01GM075273 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI DONOHUE, TIMOTHY J · 2006 to 2009
$1.1M
NIAID NIH HHS Y1-AI-4894-01NIGMS NIH HHS GM075273NIGMS NIH HHS GM15590NIGMS NIH HHS R01 GM015590NIGMS NIH HHS R01 GM075273
6 · The paper itself

Abstract

Biological systems are in a continual state of flux, which necessitates an understanding of the dynamic nature of protein abundances. The study of protein abundance dynamics has become feasible with recent improvements in mass spectrometry-based quantitative proteomics. However, a number of challenges still remain related to how best to extract biological information from dynamic proteomics data, for example, challenges related to extraneous variability, missing abundance values, and the identification of significant temporal patterns. This paper describes a strategy that addresses these issues and demonstrates its values for analyzing temporal bottom-up proteomics data using data from a Rhodobacter sphaeroides 2.4.1 time-course study.

Indexed as

Bacterial ProteinsComputational BiologyComputing MethodologiesProteomeProteomicsRhodobacter sphaeroidesTime FactorsBacterial ProteinsProteome

Identifiers

PMID18442284
PMCPMC2574618

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.