ArticleProteomics2008
Proteomic changes in rat thyroarytenoid muscle induced by botulinum neurotoxin injection.
Article in Proteomics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 18 citations in OpenAlex.
- Integrated metabolomics and proteomics analysis in children with cerebral palsy exposed to botulinum toxin-A.Pediatric research · 2025Article
- Furosemide-induced systemic dehydration alters the proteome of rabbit vocal folds.Journal of proteomics · 2022Article
- Proteomic Characterization of Senescent Laryngeal Adductor and Plantaris Hindlimb Muscles.The Laryngoscope · 2022Article
- The Effect of Botulinum Toxin A on Ischemia-Reperfusion Injury in a Rat Model.BioMed research international · 2017Article
- Enhancement of aging rat laryngeal muscles with endogenous growth factor treatment.Physiological reports · 2016Article
- The changes of serum proteome and tissular pathology in mouse induced by botulinum toxin E injection.Molecular biology reports · 2014Article
- TGF-β3 modulates the inflammatory environment and reduces scar formation following vocal fold mucosal injury in rats.Disease models & mechanisms · 2014Article
- Proteomic changes in rat gastrocnemius muscle after botulinum toxin a injection.Annals of rehabilitation medicine · 2013Article
- Proteomic analysis of a decellularized human vocal fold mucosa scaffold using 2D electrophoresis and high-resolution mass spectrometry.Biomaterials · 2013Article
- A historical and proteomic analysis of botulinum neurotoxin type/G.BMC microbiology · 2011Article
- Cross-sample validation provides enhanced proteome coverage in rat vocal fold mucosa.PloS one · 2011Article
- Translational systems biology and voice pathophysiology.The Laryngoscope · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Botulinum neurotoxin (BoNT) injection into the thyroarytenoid (TA) muscle is a commonly performed medical intervention for adductor spasmodic dysphonia. The mechanism of action of BoNT at the neuromuscular junction is well understood, however, aside from reports focused on myosin heavy chain isoform abundance, there is a paucity of data addressing the effects of therapeutic BoNT injection on the TA muscle proteome. In this study, 12 adult Sprague Dawley rats underwent unilateral TA muscle BoNT serotype A injection followed by tissue harvest at 72 h, 7 days, 14 days, and 56 days postinjection. Three additional rats were reserved as controls. Proteomic analysis was performed using 2-D SDS-PAGE followed by MALDI-MS. Vocal fold movement was significantly reduced by 72 h, with complete return of function by 56 days. Twenty-five protein spots demonstrated significant protein abundance changes following BoNT injection, and were associated with alterations in energy metabolism, muscle contractile function, cellular stress response, transcription, translation, and cell proliferation. A number of protein abundance changes persisted beyond the return of gross physiologic TA function. These findings represent the first report of BoNT-induced changes in any skeletal muscle proteome, and reinforce the utility of applying proteomic tools to the study of system-wide biological processes in normal and perturbed TA muscle function.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.