ArticleJournal of biomedical materials research. Part A2009
Comparative effects of scaffold pore size, pore volume, and total void volume on cranial bone healing patterns using microsphere-based scaffolds.
Article in Journal of biomedical materials research. Part A, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed.
- Bone Regeneration in Rat Calvaria Using 3D-Printed Scaffolds with Graded Porosity and In Vitro Degradation.ACS omega · 2025Article
- An overview of stem cells and cell products involved in trauma injury.Regenerative therapy · 2025Review
- Article
- The potent osteo-inductive capacity of bioinspired brown seaweed-derived carbohydrate nanofibrous three-dimensional scaffolds.Marine life science & technology · 2024Article
- Review
- Engineering the vasculature for islet transplantation.Acta biomaterialia · 2019Review
- Antibacterial 3D bone scaffolds for tissue engineering application.Journal of biomedical materials research. Part B, Applied biomaterials · 2019Article
- Wicking Property of Graft Material Enhanced Bone Regeneration in the Ovariectomized Rat Model.Tissue engineering and regenerative medicine · 2018Article
- Homogenous scaffold-based cranial/skull implant modelling and structural analysis-unit cell algorithm-meshless approach.Medical & biological engineering & computing · 2017Article
- Highly porous scaffolds of PEDOT:PSS for bone tissue engineering.Acta biomaterialia · 2017Article
- Collagen-grafted porous HDPE/PEAA scaffolds for bone reconstruction.Biomaterials research · 2016Article
- Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect.Journal of visualized experiments : JoVE · 2015Article
- Oxygen-tension controlled matrices for enhanced osteogenic cell survival and performance.Annals of biomedical engineering · 2014Article
- Subcritical CO2 sintering of microspheres of different polymeric materials to fabricate scaffolds for tissue engineering.Materials science & engineering. C, Materials for biological applications · 2013Article
- Viscoelasticity of repaired sciatic nerve by poly(lactic-co-glycolic acid) tubes.Neural regeneration research · 2013Article
- Percutaneous gene therapy heals cranial defects.Gene therapy · 2013Article
- Poly(lactic-co-glycolic acid) conduit for repair of injured sciatic nerve: A mechanical analysis.Neural regeneration research · 2013Article
- Tailoring of processing parameters for sintering microsphere-based scaffolds with dense-phase carbon dioxide.Journal of biomedical materials research. Part B, Applied biomaterials · 2013Article
- Biodegradable composite scaffolds incorporating an intramedullary rod and delivering bone morphogenetic protein-2 for stabilization and bone regeneration in segmental long bone defects.Acta biomaterialia · 2011Article
- BMP-2 gene-fibronectin-apatite composite layer enhances bone formation.Journal of biomedical science · 2011Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Bony craniofacial deficits resulting from injury, disease, or birth defects remain a considerable clinical challenge. In this study, microsphere-based scaffold fabrication methods were use to study the respective effects of scaffold pore size, open pore volume, and total void volume fraction on osseous tissue infiltration and bone regeneration in a critical size rat cranial defect. To compare the healing effects of these parameters, three different scaffolds types were fabricated: solid 100 microm spheres, solid 500 microm spheres, and hollow 500 microm spheres. These constructs were implanted into surgically created rat calvarial defects. By 90-days post op, results of micro computed tomography (CT) analysis showed that all scaffolds generated similar amounts of new bone which was significantly greater than untreated controls. Interestingly, the spatial distribution of new bone within the defect area varied by scaffold group. MicroCT and histological analysis demonstrated healing restricted to the dural side in the hollow 500 microm group, whereas the solid 500 microm group demonstrated healing along the dural side and within the center of the defect. Solid 100 microm groups demonstrated healing along the dural layer, periosteal layer, and within the center of the defect. These results suggest that pore size and closed void volume may both play important roles in scaffold degradation patterns and associated bone healing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.