ReviewAmerican journal of respiratory cell and molecular biology2008
Cigarette smoke triggers code red: p21CIP1/WAF1/SDI1 switches on danger responses in the lung.
Review in American journal of respiratory cell and molecular biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 31 citations in OpenAlex.
- Cellular senescence in Alzheimer's disease: from physiology to pathology.Translational neurodegeneration · 2024Review
- Genetic ablation of histone deacetylase 2 leads to lung cellular senescence and lymphoid follicle formation in COPD/emphysema.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2018Article
- RNAseq analysis of bronchial epithelial cells to identify COPD-associated genes and SNPs.BMC pulmonary medicine · 2018Article
- Article
- Soluble extracellular Klotho decreases sensitivity to cigarette smoke induced cell death in human lung epithelial cells.Toxicology in vitro : an international journal published in association with BIBRA · 2015Article
- Senescence in chronic obstructive pulmonary disease.Proceedings of the American Thoracic Society · 2012Review
- SIRT1 as a therapeutic target in inflammaging of the pulmonary disease.Preventive medicine · 2012Review
- The pathogenesis of COPD and IPF: distinct horns of the same devil?Respiratory research · 2012Review
- Suppressed expression of T-box transcription factors is involved in senescence in chronic obstructive pulmonary disease.PLoS computational biology · 2012Article
- Oxidative DNA damage in lung tissue from patients with COPD is clustered in functionally significant sequences.International journal of chronic obstructive pulmonary disease · 2011Article
- Role of mutagenicity in asbestos fiber-induced carcinogenicity and other diseases.Journal of toxicology and environmental health. Part B, Critical reviews · 2011Review
- Pulmonary epithelial neuropilin-1 deletion enhances development of cigarette smoke-induced emphysema.American journal of respiratory and critical care medicine · 2009Article
- Asbestos-induced lung diseases: an update.Translational research : the journal of laboratory and clinical medicine · 2009Review
- It takes two to tango: cigarette smoke partners with viruses to promote emphysema.The Journal of clinical investigation · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The article by Yao and coworkers in this issue (Am. J. Respir. Cell Mol. Biol. 2008;39:7-18) reveals that the cyclin-dependent kinase inhibitor p21CIP1/WAF1/SDI1 (designated hereafter as p21), which has been linked to cell cycle growth arrest due to stress or danger cell responses, may modulate alveolar inflammation and alveolar destruction, and thus enlightens our present understanding of how the lung senses injury due to cigarette smoke and integrates these responses with those that activate inflammatory pathways potentially harmful to the lung. Furthermore, the interplay of p21 and cellular processes involving cell senescence and the imbalance of cell proliferation/apoptosis may provide us with a more logical explanation of how p21, acting as a sensor of cellular stress, might have such potent and wide roles in lung responses triggered by cigarette smoke. Molecular switches, ontologically designed for the protection of the host, are now hijacked by injurious stresses (such as cigarette smoke), leading to organ damage.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.