ArticleToxicologic pathology2008
Immunolocalization of Kim-1, RPA-1, and RPA-2 in kidney of gentamicin-, mercury-, or chromium-treated rats: relationship to renal distributions of iNOS and nitrotyrosine.
Article in Toxicologic pathology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 81 citations in OpenAlex.
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- Oral Exposure to Titanium Dioxide E171 and Zinc Oxide Nanoparticles Induces Multi-Organ Damage in Rats: Role of Ceramide.International journal of molecular sciences · 2024Article
- Renal Papillary Necrosis (RPN) in an African Population: Disease Patterns, Relevant Pathways, and Management.Biomedicines · 2022Review
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- Ameliorative effect of virgin olive oil against nephrotoxicity following sub-chronic administration of ethephon in male rats.Journal of traditional and complementary medicine · 2020Article
- Effect ofMedicina (Kaunas, Lithuania) · 2019Article
- Gentamicin induced acute renal damage and its evaluation using urinary biomarkers in rats.Toxicology reports · 2019Article
- Biological alterations in renal and hepatic tissues by a novel gold (III) anti-cancerous compound.Iranian journal of basic medical sciences · 2018Article
- Aminoglycoside-induced nephrotoxicity in children.Pediatric nephrology (Berlin, Germany) · 2017Review
- Increased expression of kidney injury molecule-1 and matrix metalloproteinase-3 in severeInternational journal of clinical and experimental pathology · 2017Article
- Biomarkers of mercury toxicity: Past, present, and future trends.Journal of toxicology and environmental health. Part B, Critical reviews · 2017Review
- Toxicological significance of renal Bcrp: Another potential transporter in the elimination of mercuric ions from proximal tubular cells.Toxicology and applied pharmacology · 2015Article
- Alpha-lipoic acid attenuates lipopolysaccharide-induced kidney injury.Clinical and experimental nephrology · 2015Article
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12 authors at 4 institutions in 2 countries.
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Abstract
Immunohistochemical studies for kidney injury molecule-1 (Kim-1), renal papillary antigen-1 (RPA-1), and renal papillary antigen-2 (RPA-2) were conducted to explore their relationship to inducible nitric oxide synthase (iNOS) and nitrotyrosine expression. Male Sprague-Dawley rats were exposed to gentamicin (100 mg/kg/day Gen, sc, for 3 days), mercury (0.25 mg Hg/kg, iv, single dose), or chromium (5 mg Cr/kg, sc, single dose) and kidney tissue was examined 24 hours or 72 hours after the last dose of the nephrotoxicant. Another group of kidneys was evaluated 24 hours after rats were administered 3 daily doses (50, 100, 150, 200, or 300 mg/kg/day) of Gen. Gen- and Cr-treated rats exhibited increased immunoreactivity of Kim-1, RPA-1, and RPA-2 largely in the S1/S2 segments and to a lesser extent in the S3 segments of the proximal tubule of the kidney, whereas Hg-treated rats showed increased immunoreactivity of Kim-1, RPA-1, and RPA-2 in the S3 segments. Up-regulation of Kim-1, RPA-1, and RPA-2 expression correlated with injured tubular epithelial cells and also correlated with immunoreactivity of iNOS and nitrotyrosine. It is possible that iNOS activation with nitrotyrosine production in injured nephron segments may be involved in the induction of Kim-1, RPA-1, and RPA-2 following exposure to nephrotoxicants.
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