ArticleApplied and environmental microbiology2008
Mycelium differentiation and antibiotic production in submerged cultures of Streptomyces coelicolor.
Article in Applied and environmental microbiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers.
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Who cites it
74 citing papers in PubMed.
- The Flavonoids Daidzein and Genistein Induce Wall-Deficient Cell Formation in Streptomyces coelicolor Under Hyperosmotic Stress.Microbial biotechnology · 2026Article
- Inactivation of the sco2730/2731 copper chaperone-transporter system in Streptomyces coelicolor and its orthologs in Streptomyces venezuelae, together with chromosomal end deletion, greatly enhances secondary metabolism.Microbial cell factories · 2026Article
- Bacterial Espresso: Evaluating Accelerated Solvent Extraction for Selected Metabolite Recovery fromJournal of natural products · 2026Article
- Extracellular activity of a bacterial protease associated with reduced phage infectivity.PloS one · 2026Article
- Lon protease reprograms cellular physiology ofFrontiers in microbiology · 2026Article
- Engineering bacterial cell morphology for the design of robust cell factories.Biochemistry and biophysics reports · 2025Review
- Peptidoglycan-reshuffling proteins SCO0954, SCO1758, SCO4439, and SCO4440 modulate the formation of wall-deficient cells in Streptomyces coelicolor under hyperosmotic sucrose stress.Scientific reports · 2025Article
- Assessing the effect of temperature onMicrobiology (Reading, England) · 2025Article
- The DeoR-like pleiotropic regulator SCO1897 controls specialised metabolism, sporulation, spore germination, and phosphorus accumulation in Streptomyces coelicolor.Communications biology · 2024Article
- Simultaneous Two- and Three-Photon Deep Imaging of Autofluorescence in Bacterial Communities.Sensors (Basel, Switzerland) · 2024Article
- Description ofFrontiers in microbiology · 2024Article
- Genetics of conditional extended mycelial cell viability ofFrontiers in microbiology · 2024Article
- A High-Throughput Method Based on Microculture Technology for Screening of High-Yield Strains of Tylosin-ProducingJournal of microbiology and biotechnology · 2023Article
- The DNA cytosine methylome revealed two methylation motifs in the upstream regions of genes related to morphological and physiological differentiation in Streptomyces coelicolor A(3)2 M145.Scientific reports · 2023Article
- Cytoplasmic contractile injection systems mediate cell death in Streptomyces.Nature microbiology · 2023Article
- Antibiofilm activity from endophyte bacteria, Vibrio cholerae strains, and actinomycetes isolates in liquid and solid culture.BMC microbiology · 2023Article
- A contractile injection system is required for developmentally regulated cell death in Streptomyces coelicolor.Nature communications · 2023Article
- FtsZ phosphorylation pleiotropically affects Z-ladder formation, antibiotic production, and morphogenesis in Streptomyces coelicolor.Antonie van Leeuwenhoek · 2023Article
- Polymeric Encapsulate ofPolymers · 2022Article
- Phosphoproteome Dynamics of Streptomyces rimosus during Submerged Growth and Antibiotic Production.mSystems · 2022Article
14 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite the fact that most industrial processes for secondary metabolite production are performed with submerged cultures, a reliable developmental model for Streptomyces under these culture conditions is lacking. With the exception of a few species which sporulate under these conditions, it is assumed that no morphological differentiation processes take place. In this work, we describe new developmental features of Streptomyces coelicolor A3(2) grown in liquid cultures and integrate them into a developmental model analogous to the one previously described for surface cultures. Spores germinate as a compartmentalized mycelium (first mycelium). These young compartmentalized hyphae start to form pellets which grow in a radial pattern. Death processes take place in the center of the pellets, followed by growth arrest. A new multinucleated mycelium with sporadic septa (second mycelium) develops inside the pellets and along the periphery, giving rise to a second growth phase. Undecylprodigiosin and actinorhodin antibiotics are produced by this second mycelium but not by the first one. Cell density dictates how the culture will behave in terms of differentiation processes and antibiotic production. When diluted inocula are used, the growth arrest phase, emergence of a second mycelium, and antibiotic production are delayed. Moreover, pellets are less abundant and have larger diameters than in dense cultures. This work is the first to report on the relationship between differentiation processes and secondary metabolite production in submerged Streptomyces cultures.
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