ReviewCurrent opinion in structural biology2008
Core principles of intramembrane proteolysis: comparison of rhomboid and site-2 family proteases.
Review in Current opinion in structural biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed.
- Metallopeptidase Stp1 activates the transcription factor Sre1 in the carotenogenic yeastJournal of lipid research · 2020Article
- A Golgi rhomboid protease Rbd2 recruits Cdc48 to cleave yeast SREBP.The EMBO journal · 2016Article
- Biochemical and structural insights into intramembrane metalloprotease mechanisms.Biochimica et biophysica acta · 2013Review
- The roles of intramembrane proteases in protozoan parasites.Biochimica et biophysica acta · 2013Review
- Residues in conserved loops of intramembrane metalloprotease SpoIVFB interact with residues near the cleavage site in pro-σK.Journal of bacteriology · 2013Article
- Features of Pro-σK important for cleavage by SpoIVFB, an intramembrane metalloprotease.Journal of bacteriology · 2013Article
- An internal water-retention site in the rhomboid intramembrane protease GlpG ensures catalytic efficiency.Structure (London, England : 1993) · 2012Article
- Three-dimensional structure of the signal peptide peptidase.The Journal of biological chemistry · 2011Article
- CREST--a large and diverse superfamily of putative transmembrane hydrolases.Biology direct · 2011Article
- Expansion of type II CAAX proteases reveals evolutionary origin of γ-secretase subunit APH-1.Journal of molecular biology · 2011Article
- Sequence analysis and verification of Eimeria tenella rhomboid bait plasmid suitability for CytoTrap yeast two-hybrid system.Parasitology research · 2011Article
- Participation of transmembrane domain 1 of presenilin 1 in the catalytic pore structure of the γ-secretase.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- New insights into S2P signaling cascades: regulation, variation, and conservation.Protein science : a publication of the Protein Society · 2010Review
- The PARL family of mitochondrial rhomboid proteases.Seminars in cell & developmental biology · 2010Review
- Taking the plunge: integrating structural, enzymatic and computational insights into a unified model for membrane-immersed rhomboid proteolysis.The Biochemical journal · 2010Review
- Intramembrane proteolytic cleavage of a membrane-tethered transcription factor by a metalloprotease depends on ATP.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Cleavage of RseA by RseP requires a carboxyl-terminal hydrophobic amino acid following DegS cleavage.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Making the cut: central roles of intramembrane proteolysis in pathogenic microorganisms.Nature reviews. Microbiology · 2009Review
- Structure and mechanism of intramembrane protease.Seminars in cell & developmental biology · 2009Review
- Toward structural elucidation of the gamma-secretase complex.Structure (London, England : 1993) · 2009Review
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Cleavage of proteins within their membrane-spanning segments is an ancient regulatory mechanism that has evolved to control a myriad of cellular processes in all forms of life. Although three mechanistic families of enzymes have been discovered that catalyze hydrolysis within the water-excluding environment of the membrane, how they achieve this improbable reaction has been both a point of controversy and skepticism. The crystal structures of rhomboid and site-2 protease, two different classes of intramembrane proteases, have been solved recently. Combined with current biochemical analyses, this advance provides an unprecedented view of how nature has solved the problem of facilitating hydrolysis within membranes in two independent instances. We focus on detailing the similarities between these unrelated enzymes to define core biochemical principles that govern this conserved regulatory mechanism.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.