ArticleThe Journal of allergy and clinical immunology2008
Dust mite exposure modifies the effect of functional IL10 polymorphisms on allergy and asthma exacerbations.
Article in The Journal of allergy and clinical immunology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00021840 (Genetic Epidemiology of Asthma in Costa Rica), which is not on this map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Genetic Epidemiology of Asthma in Costa Rica
Who cites it
28 citing papers in PubMed, 59 citations in OpenAlex.
- Gene-by-environment effect of house dust mite on purinergic receptor P2Y12 (P2RY12) and lung function in children with asthma.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2012Trial
- MMP12, lung function, and COPD in high-risk populations.The New England journal of medicine · 2009Trial
- Variants in TGFB1, dust mite exposure, and disease severity in children with asthma.American journal of respiratory and critical care medicine · 2009Trial
- Mother's smoking habits affects IL10 methylation but not asthma in Ecuadorian children.Molecular genetics & genomic medicine · 2024Article
- Polymorphic markers of several immune regulatory genes modulate the susceptibility for eczema and related phenotypes in children.Translational pediatrics · 2024Article
- House dust mite allergy in Malaysia: review of research gaps in the current scenario and the way forward.Experimental & applied acarology · 2023Review
- Genome-wide interaction study of dust mite allergen on lung function in children with asthma.The Journal of allergy and clinical immunology · 2017Article
- Genetic association and epistatic interaction of the interleukin-10 signaling pathway in pediatric inflammatory bowel disease.World journal of gastroenterology · 2017Article
- International consensus (ICON) on: clinical consequences of mite hypersensitivity, a global problem.The World Allergy Organization journal · 2017Article
- Personalized management of asthma exacerbations: lessons from genetic studies.Expert review of precision medicine and drug development · 2016Article
- Genome-wide expression profiles identify potential targets for gene-environment interactions in asthma severity.The Journal of allergy and clinical immunology · 2015Article
- Asthma in Latin America.Thorax · 2015Review
- Genetic correlation of SOCS3 polymorphisms with infantile asthma: an evidence based on a case-control study.International journal of clinical and experimental pathology · 2015Article
- Stress and asthma: novel insights on genetic, epigenetic, and immunologic mechanisms.The Journal of allergy and clinical immunology · 2014Review
- Asthma in Hispanics. An 8-year update.American journal of respiratory and critical care medicine · 2014Review
- Association of cytokines in individuals sensitive and insensitive to dust mites in a Brazilian population.PloS one · 2014Article
- Interleukin 10 (IL10) and transforming growth factor β1 (TGFβ1) gene polymorphisms in persistent IgE-mediated cow's milk allergy.Clinics (Sao Paulo, Brazil) · 2013Article
- Coassociations between IL10 polymorphisms, IL-10 production, helminth infection, and asthma/wheeze in an urban tropical population in Brazil.The Journal of allergy and clinical immunology · 2013Article
- Article
- The challenge of asthma in minority populations.Clinical reviews in allergy & immunology · 2012Review
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Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundThe allergenicity of dust mite exposure might be dependent on variants in the gene for IL-10 (IL10).
objectivesTo evaluate whether dust mite exposure modifies the effect of single nucleotide polymorphisms (SNPs) in IL10 on allergy and asthma exacerbations.
methodsWe genotyped 6 SNPs in IL10 in 417 Costa Rican children and 503 white children in the Childhood Asthma Management Program (CAMP) with asthma and their parents. We used family-based and population-based approaches to test for interactions between IL10 SNPs and dust mite allergen on serum IgE to dust mite in Costa Rica and on asthma exacerbations in Costa Rica and CAMP.
resultsDust mite exposure significantly modified the relation between 3 SNPs in IL10 (rs1800896, rs3024492, and rs3024496) and IgE to dust mite in Costa Rica (P for interaction, .0004 for SNP rs1800896). For each of these SNPs, homozygosity for the minor allele was associated with increased levels of IgE to dust mite with increased dust mite exposure. Homozygosity for the minor allele of each of the 3 SNPs was associated with increased risk of occurrence (approximately 3-fold to 39-fold increase) and frequency of asthma exacerbations among children exposed to > or = 10 microg/g dust mite allergen in Costa Rica. Similar results were obtained for 2 of these SNPs (rs1800896 and rs3024496) among white children in CAMP.
conclusionOur findings suggest that dust mite allergen levels modify the effect of IL10 SNPs on allergy and asthma exacerbations and may partly explain conflicting findings in this field.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.