Evidence map›Paper›PMID 18440579›Full record

ArticleVision research2008

Modulation of horizontal cell function by dopaminergic ligands in mammalian retina.

Renate Pflug, Ralph Nelson, Sonja Huber, Herbert Reitsamer

Open access · greenAbstract read
In one paragraph

Article in Vision research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Role of dopamine in distal retina.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2014
    Review
  6. Article
  7. Article
  8. Illuminating rationale and uses for light therapy.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2009
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Renate PflugCenter for Physiology and Pathophysiology, Department of Physiology, Medical University of Vienna, Schwarzspanierstrasse 17, 1090 Vienna, Austria. renate.pflug@meduniwien.ac.at <renate.pflug@meduniwien.ac.at>
Ralph Nelson
Sonja Huber
Herbert Reitsamer
Medical University of Vienna · ATNational Institutes of Health · USParacelsus Medical University · AT

Funding

Structure And Function In Retinal NeuronsZIANS002631 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI NELSON, RALPH F · 2009 to 2023
$6.6M
STRUCTURE AND FUNCTION IN RETINAL NEURONSZ01NS002631 · NINDS · NEUROLOGICAL DISORDERS AND STROKE · PI NELSON, RALPH F · 1985 to 2008
$726k
Intramural NIH HHS Z01 NS002631
6 · The paper itself

Abstract

Light responses of rabbit horizontal cell somata (HC) to flickering light stimuli recorded with sharp electrodes consist of a distinctive flicker component superimposed on a sustained hyperpolarisation. Activation of dopamine D1/D5 receptors depolarises HC dark membrane potential and suppresses the flicker component of responses to photopic stimuli without affecting the sustained hyperpolarising response component. Waveforms of responses to scotopic stimuli are preserved. Similar response modulation was observed in depolarising cells of the inner retina, suggesting that activation of D1/D5 receptors of HC causes modification of cone signal transmission to higher order neurons. The impact of dopamine D1/D5 receptor activation on the function of HC in the light stimulated retina is discussed.

Indexed as

2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepineAnimalsApomorphineDark AdaptationDopamineDopamine AgonistsFeedback, PhysiologicalMammalsMembrane PotentialsPhotic StimulationQuinpiroleRabbitsReceptors, DopamineRetinaRetinal Cone Photoreceptor CellsRetinal Rod Photoreceptor Cells2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepineApomorphineDopamineDopamine AgonistsQuinpiroleReceptors, Dopamine

Identifiers

PMID18440579
PMCPMC5244834
OpenAlexW2048647584

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.