ReviewCancer letters2008
Nitric oxide as a target of complementary and alternative medicines to prevent and treat inflammation and cancer.
Review in Cancer letters, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 83 citations in OpenAlex.
- Methanol Extract ofMolecules (Basel, Switzerland) · 2024Article
- L-theanine alleviates myocardial ischemia/reperfusion injury by suppressing oxidative stress and apoptosis through activation of the JAK2/STAT3 pathway in mice.Molecular medicine (Cambridge, Mass.) · 2024Article
- Spirulina platensis as a growth booster for broiler; Insights into their nutritional, molecular, immunohistopathological, and microbiota modulating effects.BMC veterinary research · 2024Article
- Indole-3-Carbinol (I3C) Protects the Heart From Ischemia/Reperfusion Injury by Inhibiting Oxidative Stress, Inflammation, and Cellular Apoptosis in Mice.Frontiers in pharmacology · 2022Article
- 9‑Hydroxy‑isoegomaketone inhibits LPS‑induced NO and inflammatory cytokine production in RAW264.7 cells.Molecular medicine reports · 2021Article
- Single-Walled Carbon Nanotube Sensor Platform for the Study of Extracellular Analytes.ACS applied nano materials · 2021Article
- Bioactive Secondary Metabolites from Octocoral-Associated Microbes-New Chances for Blue Growth.Marine drugs · 2018Review
- Oxidative damage in the progression of chronic liver disease to hepatocellular carcinoma: an intricate pathway.World journal of gastroenterology · 2014Review
- Evaluation of antioxidant and antiangiogenic properties of caesalpinia echinata extracts.Journal of Cancer · 2014Article
- Synthesis of 2-arylindole derivatives and evaluation as nitric oxide synthase and NFκB inhibitors.Organic & biomolecular chemistry · 2012Article
- Antioxidant activities of Indigofera cassioides Rottl. Ex. DC. using various in vitro assay models.Asian Pacific journal of tropical biomedicine · 2012Article
- BDMC33, A curcumin derivative suppresses inflammatory responses in macrophage-like cellular system: role of inhibition in NF-κB and MAPK signaling pathways.International journal of molecular sciences · 2012Article
- Role of TLR2-dependent inflammation in metastatic progression.Annals of the New York Academy of Sciences · 2011Review
- Article
- American ginseng suppresses colitis through p53-mediated apoptosis of inflammatory cells.Cancer prevention research (Philadelphia, Pa.) · 2010Article
- Suppression of inflammatory mediators by cruciferous vegetable-derived indole-3-carbinol and phenylethyl isothiocyanate in lipopolysaccharide-activated macrophages.Mediators of inflammation · 2010Article
- Inflammation and cancer: interweaving microRNA, free radical, cytokine and p53 pathways.Carcinogenesis · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Nitric oxide (NO) and associated reactive nitrogen species (RNS) are involved in many physiological functions. There has been an ongoing debate to whether RNS can inhibit or perpetuate chronic inflammation and associated carcinogenesis. Although the final outcome depends on the genetic make-up of its target, the surrounding microenvironment, the activity and localization of nitric oxide synthase (NOS) isoforms, and overall levels of NO/RNS, evidence is accumulating that in general, RNS drive inflammation and cancers associated with inflammation. To this end, many complementary and alternative medicines (CAMs) that work in chemoprevention associated with chronic inflammation, are inhibitors of excessive NO observed in inflammatory conditions. Here, we review recent literature outlining a role of NO/RNS in chronic inflammation and cancer, and point toward NO as one of several targets for the success of CAMs in treating chronic inflammation and cancer associated with this inflammation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.