ArticleMolecular cell2008
Architecture of a serine recombinase-DNA regulatory complex.
Article in Molecular cell, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 58 citations in OpenAlex.
- In vitro properties of large serine integrase hybrids derived from ϕC31 and TG1 integrases.Nucleic acids research · 2026Article
- Large serine integrases utilise scavenged phage proteins as directionality cofactors.Nucleic acids research · 2025Article
- Structural basis of directionality control in large serine integrases.bioRxiv : the preprint server for biology · 2025Article
- Structural basis for topological regulation of Tn3 resolvase.Nucleic acids research · 2023Article
- Multiple serine transposase dimers assemble the transposon-end synaptic complex during ISeLife · 2018Article
- Snapshots of a molecular swivel in action.Nucleic acids research · 2018Article
- Small serine recombination systems ParA-MRS and CinH-RS2 perform precise excision of plastid DNA.Plant biotechnology journal · 2017Article
- The regulatory role of DNA supercoiling in nucleoprotein complex assembly and genetic activity.Biophysical reviews · 2016Review
- Gene stacking by recombinases.Plant biotechnology journal · 2016Review
- Deciphering the Roles of Multicomponent Recognition Signals by the AAA+ Unfoldase ClpX.Journal of molecular biology · 2015Article
- Serine Resolvases.Microbiology spectrum · 2015Review
- Site-specific DNA Inversion by Serine Recombinases.Microbiology spectrum · 2015Article
- The ins and outs of serine integrase site-specific recombination.Current opinion in structural biology · 2014Review
- A proposed mechanism for IS607-family serine transposases.Mobile DNA · 2013Article
- Multiple interfaces between a serine recombinase and an enhancer control site-specific DNA inversion.eLife · 2013Article
- A comprehensive approach to zinc-finger recombinase customization enables genomic targeting in human cells.Nucleic acids research · 2013Article
- Crystal structure of an intermediate of rotating dimers within the synaptic tetramer of the G-segment invertase.Nucleic acids research · 2013Article
- The site-specific integration reaction of Listeria phage A118 integrase, a serine recombinase.Mobile DNA · 2013Article
- Identification of natural and artificial DNA substrates for light-activated LOV-HTH transcription factor EL222.Biochemistry · 2012Article
- Characterization of DNA sequences required for the CcrAB-mediated integration of staphylococcal cassette chromosome mec, a Staphylococcus aureus genomic island.Journal of bacteriology · 2012Article
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
An essential feature of many site-specific recombination systems is their ability to regulate the direction and topology of recombination. Resolvases from the serine recombinase family assemble an interwound synaptic complex that harnesses negative supercoiling to drive the forward reaction and promote recombination between properly oriented sites. To better understand the interplay of catalytic and regulatory functions within these synaptic complexes, we have solved the structure of the regulatory site synapse in the Sin resolvase system. It reveals an unexpected synaptic interface between helix-turn-helix DNA-binding domains that is also highlighted in a screen for synapsis mutants. The tetramer defined by this interface provides the foundation for a robust model of the synaptic complex, assembled entirely from available crystal structures, that gives insight into how the catalytic activity of Sin and other serine recombinases may be regulated.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.