ReviewNeuroscience and biobehavioral reviews2008
Genetic variation in cortico-amygdala serotonin function and risk for stress-related disease.
Review in Neuroscience and biobehavioral reviews, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 118 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
118 citing papers in PubMed, 265 citations in OpenAlex.
- A randomized controlled trial of lorcaserin and lifestyle counselling for weight loss maintenance: changes in emotion- and stress-related eating, food cravings and appetite.Clinical obesity · 2018Trial
- Fluctuations in [¹¹C]SB207145 PET binding associated with change in threat-related amygdala reactivity in humans.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Trial
- The conditioning of intervention effects on early adolescent alcohol use by maternal involvement and dopamine receptor D4 (DRD4) and serotonin transporter linked polymorphic region (5-HTTLPR) genetic variants.Development and psychopathology · 2015Trial
- Reduced serotonin transporter availability decreases prefrontal control of the amygdala.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Trial
- Impact of serotonin transporter deficiency on parvalbumin- and neuropeptide Y-producing neurons of the lateral and basolateral amygdalar nuclei.Journal of neural transmission (Vienna, Austria : 1996) · 2026Article
- Placental serotonergic system dysregulation is associated with early impairments in infant neurodevelopment.Frontiers in endocrinology · 2025Article
- Exploring the therapeutic potential of psychedelics: Fear extinction mechanisms and amygdala modulation.Psychedelics · 2025Article
- Unraveling the Serotonergic Mechanism of Stress-Related Anxiety: Focus on Co-Treatment with Resveratrol and Selective Serotonin Reuptake Inhibitors.Biomedicines · 2024Article
- The relationship between depression, anxiety and lower urinary tract symptoms in men.Prostate international · 2024Article
- Relationship between Mental Disorders, Smoking or Alcoholism and Benign Prostate Disease.Clinics and practice · 2024Article
- Neural signatures of default mode network subsystems in first-episode, drug-naive patients with major depressive disorder after 6-week thought induction psychotherapy treatment.Brain communications · 2024Article
- Alleviating anxiety and taming trauma: Novel pharmacotherapeutics for anxiety disorders and posttraumatic stress disorder.Neuropharmacology · 2023Review
- Listening to your partner: serotonin increases male responsiveness to female vocal signals in mice.Frontiers in human neuroscience · 2023Article
- Amygdala dynorphin/κ opioid receptor system modulates depressive-like behavior in mice following chronic social defeat stress.Acta pharmacologica Sinica · 2022Article
- Antidepressant activity of pharmacological and genetic deactivation of the small-conductance calcium-activated potassium channel subtype-3.Psychopharmacology · 2022Article
- Maternal High-Fat Diet ModulatesNutrients · 2021Article
- Early social deprivation shapes neuronal programming of the social decision-making network in a cooperatively breeding fish.Molecular ecology · 2021Article
- Region- and receptor-specific effects of chronic social stress on the central serotonergic system in mice.IBRO neuroscience reports · 2021Article
- Association between Lower Urinary Tract Symptoms and Sleep Quality of Patients with Depression.Medicina (Kaunas, Lithuania) · 2021Article
- Improved visual discrimination learning in mice with partial 5-HT2B gene deletion.Neuroscience letters · 2020Article
58 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
The serotonin system is strongly implicated in the pathophysiology and therapeutic alleviation of stress-related disorders such as anxiety and depression. Serotonergic modulation of the acute response to stress and the adaptation to chronic stress is mediated by a myriad of molecules controlling serotonin neuron development (Pet-1), synthesis (tryptophan hydroxylase 1 and 2 isozymes), packaging (vesicular monoamine transporter 2), actions at presynaptic and postsynaptic receptors (5-HT1A, 5-HT1B, 5-HT2A, 5-HT2C, 5-HT3A, 5-HT4, 5-HT5A, 5-HT6, 5-HT7), reuptake (serotonin transporter), and degradation (monoamine oxidase A). A growing body of evidence from preclinical rodents models, and especially genetically modified mice and inbred mouse strains, has provided significant insight into how genetic variation in these molecules can affect the development and function of a key neural circuit between the dorsal raphe nucleus, medial prefrontal cortex and amygdala. By extension, such variation is hypothesized to have a major influence on individual differences in the stress response and risk for stress-related disease in humans. The current article provides an update on this rapidly evolving field of research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.