ReviewThe Psychiatric clinics of North America2008
Stress, genes and the biology of suicidal behavior.
Review in The Psychiatric clinics of North America, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 2 syntheses or guidelines pooled it, 139 citations in OpenAlex.
- The relation between child maltreatment and adolescent suicidal behavior: a systematic review and critical examination of the literature.Clinical child and family psychology review · 2013Pooled it
- White matter hyperintensities and their association with suicidality in major affective disorders: a meta-analysis of magnetic resonance imaging studies.CNS spectrums · 2010Pooled it
- Rapid resolution of suicidal ideation after a single infusion of an N-methyl-D-aspartate antagonist in patients with treatment-resistant major depressive disorder.The Journal of clinical psychiatry · 2010Trial
- Social disconnection integrates genetic and proteomic risks in suicidal ideation and depression.Translational psychiatry · 2026Article
- Sex differences in correlates of suicide attempts in Chinese Han first-episode and drug-naïve major depressive disorder with comorbid subclinical hypothyroidism: A cross-sectional study.Brain and behavior · 2024Article
- Relationship of stress-reactive cortisol to suicidal intent of prior attempts in major depression.Psychiatry research · 2023Article
- A Stress Protein-Based Suicide Prediction Score and Relationship to Reported Early-Life Adversity and Recent Life Stress.The international journal of neuropsychopharmacology · 2023Article
- Is It Correct to Consider Caustic Ingestion as a Nonviolent Method of Suicide? A Retrospective Analysis and Psychological Considerations.International journal of environmental research and public health · 2023Article
- DNA Methylation of Genes Involved in the HPA Axis in Presence of Suicide Behavior: A Systematic Review.Brain sciences · 2023Review
- Suicide Biomarkers to Predict Risk, Classify Diagnostic Subtypes, and Identify Novel Therapeutic Targets: 5 Years of Promising Research.The international journal of neuropsychopharmacology · 2022Review
- Suicidality in Epilepsy: Does It Share Common Pathogenic Mechanisms with Epilepsy?Current topics in behavioral neurosciences · 2022Observational
- Review
- Clinical Features of Psychotic Disorders: Comparing Categorical and Dimensional Models.Psychiatric research and clinical practice · 2021Article
- Suicide attempt following sickness absence and disability pension due to common mental disorders: a prospective Swedish twin study.Social psychiatry and psychiatric epidemiology · 2020Article
- Development and content validity of the behavioral assessment screening tool (BASTDisability and rehabilitation · 2019Article
- Dopamine and Stress System Modulation of Sex Differences in Decision Making.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Article
- Assessment of Whole-Exome Sequence Data in Attempted Suicide within a Bipolar Disorder Cohort.Molecular neuropsychiatry · 2017Article
- Biomarkers of Suicide Attempt Behavior: Towards a Biological Model of Risk.Current psychiatry reports · 2017Review
- Understanding epigenetic architecture of suicide neurobiology: A critical perspective.Neuroscience and biobehavioral reviews · 2017Review
- The Life Span Model of Suicide and Its Neurobiological Foundation.Frontiers in neuroscience · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Suicidal behavior is partly heritable. Studies seeking the responsible candidate genes have examined genes involved in neurotransmitter systems shown to have altered function in suicide and attempted suicide. These neurotransmitter systems include the serotonergic, noradrenergic, and dopaminergic systems and the hypothalamic-pituitary-adrenal axis. With some exceptions, most notably the serotonin transporter gene promoter polymorphism (HTTLPR), replication of candidate gene association studies findings has been difficult. This article reviews current knowledge of specific gene effects and gene-environment interactions that influence risk for suicidal behavior. Effects of childhood stress on development and how it influences adult responses to current stress are shown to be relevant for mood disorders, aggressive/impulsive traits, and suicidal behavior.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.