ArticleBMC medical genetics2008
Association between promoter -1607 polymorphism of MMP1 and lumbar disc disease in Southern Chinese.
Article in BMC medical genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Strategy to Estimate Sample Sizes to Justify the Association between MMP1 SNP and Osteoarthritis.Genes · 2022Pooled it
- Association between the MMP-1-1607 1G/2G Polymorphism and Osteoarthritis Risk: A Systematic Review and Meta-Analysis.BioMed research international · 2020Pooled it
- Pooled it
- Role of genetic polymorphisms in residual ridge resorption of mandible - A scoping review.The Japanese dental science review · 2025Review
- Can Implementation of Genetics and Pharmacogenomics Improve Treatment of Chronic Low Back Pain?Pharmaceutics · 2020Review
- Targeting ELTD1, an angiogenesis marker for glioblastoma (GBM), also affects VEGFR2: molecular-targeted MRI assessment.American journal of nuclear medicine and molecular imaging · 2019Article
- Association of matrix metalloprotease 1, 3, and 12 polymorphisms with rheumatic heart disease in a Chinese Han population.BMC medical genetics · 2018Article
- Matrix metalloproteinase-1 promoter -1607 bp 1G/2G polymorphism associated with increased risk of spinal tuberculosis in Southern Chinese Han population.Journal of clinical laboratory analysis · 2017Article
- Serum levels of the proinflammatory cytokine interleukin-6 vary based on diagnoses in individuals with lumbar intervertebral disc diseases.Arthritis research & therapy · 2016Article
- Genetic Alterations in Intervertebral Disc Disease.Frontiers in surgery · 2016Review
- Novel diagnostic and prognostic methods for disc degeneration and low back pain.The spine journal : official journal of the North American Spine Society · 2015Review
- Association of matrix metalloproteinase 1 gene promoter mutation and residual ridge resorption in edentulous patients of South Indian origin.Journal of pharmacy & bioallied sciences · 2015Article
- Expression and regulation of metalloproteinases and their inhibitors in intervertebral disc aging and degeneration.The spine journal : official journal of the North American Spine Society · 2013Review
- Genetic polymorphisms associated with intervertebral disc degeneration.The spine journal : official journal of the North American Spine Society · 2013Review
- Rat tail static compression model mimics extracellular matrix metabolic imbalances of matrix metalloproteinases, aggrecanases, and tissue inhibitors of metalloproteinases in intervertebral disc degeneration.Arthritis research & therapy · 2012Article
- Association of matrix metalloproteinase-1 gene polymorphism with glioblastoma multiforme in a northern Indian population.Journal of neuro-oncology · 2011Article
- Modic changes and interleukin 1 gene locus polymorphisms in occupational cohort of middle-aged men.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2009Article
- MMP-1 polymorphism and its relationship to pathological processes.Journal of biosciences · 2009Review
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMatrix metalloproteinases (MMPs) are involved in the degradation of the extracellular matrix of the intervertebral disc. A SNP for guanine insertion/deletion (G/D), the -1607 promoter polymorphism, of the MMP1 gene was found significantly affecting promoter activity and corresponding transcription level. Hence it is a good candidate for genetic studies in DDD.
methodsSouthern Chinese volunteers between 18 and 55 years were recruited from the population. DDD in the lumbar spine was defined by MRI using Schneiderman's classification. Genomic DNA was isolated from the leukocytes and genotyping was performed using the Sequenom platform. Association and Hardy-Weinberg equilibrium checking were assessed by Chi-square test and Mann-Whitney U test.
resultsOur results showed substantial evidence of association between -1607 promoter polymorphism of MMP1 and DDD in the Southern Chinese subjects. D allelic was significantly associated with DDD (p value = 0.027, odds ratio = 1.41 with 95% CI = 1.04-1.90) while Genotypic association on the presence of D allele was also significantly associated with DDD (p value = 0.046, odds ratio = 1.50 with 95% CI = 1.01-2.24). Further age stratification showed significant genotypic as well as allelic association in the group of over 40 years (genotypic: p value = 0.035, odds ratio = 1.617 with 95% CI = 1.033-2.529; allelic: p value = 0.033, odds ratio = 1.445 with 95% CI = 1.029-2.029). Disc bulge, annular tears and the Schmorl's nodes were not associated with the D allele.
conclusionWe demonstrated that individuals with the presence of D allele for the -1607 promoter polymorphism of MMP1 are about 1.5 times more susceptible to develop DDD when compared with those having G allele only. Further association was identified in individuals over 40 years of age. Disc bulge, annular tear as well as Schmorl's nodes were not associated with this polymorphism.
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