ArticleBMC neuroscience2008
Identification of Tmem10/Opalin as a novel marker for oligodendrocytes using gene expression profiling.
Article in BMC neuroscience, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 50 citations in OpenAlex.
- Altered oligodendroglial cell development and increased myelination in SCN2A gain-of-function-linked epilepsy.Acta neuropathologica communications · 2026Article
- AI-based characterization of Alzheimer's disease phenotypes from population-scale single-cell data.Nature medicine · 2026Article
- R4ST: a reference-guided graph-generative model for robust reconstruction of spatial transcriptomic profiles.Bioinformatics (Oxford, England) · 2026Article
- CellScope: high-performance cell atlas workflow with tree-structured representation.Nature communications · 2025Article
- Embryonic origins of forebrain oligodendrocytes revisited by combinatorial genetic fate mapping.eLife · 2024Article
- ENGEP: advancing spatial transcriptomics with accurate unmeasured gene expression prediction.Genome biology · 2023Article
- Nipah Virus Bangladesh Infection Elicits Organ-Specific Innate and Inflammatory Responses in the Marmoset Model.The Journal of infectious diseases · 2023Article
- Whole Exome Sequencing in Multi-Incident Families Identifies Novel Candidate Genes for Multiple Sclerosis.International journal of molecular sciences · 2022Article
- TRPV2: A Key Player in Myelination Disorders of the Central Nervous System.International journal of molecular sciences · 2022Article
- The CNS Myelin Proteome: Deep Profile and Persistence After Post-mortem Delay.Frontiers in cellular neuroscience · 2020Article
- TMEM10 Promotes Oligodendrocyte Differentiation and is Expressed by Oligodendrocytes in Human Remyelinating Multiple Sclerosis Plaques.Scientific reports · 2019Article
- Necrotizing enterocolitis is associated with acute brain responses in preterm pigs.Journal of neuroinflammation · 2018Article
- Characteristics of allelic gene expression in human brain cells from single-cell RNA-seq data analysis.BMC genomics · 2017Article
- Remarkable Stability of Myelinating Oligodendrocytes in Mice.Cell reports · 2017Article
- Mammalian-Specific Central Myelin Protein Opalin Is Redundant for Normal Myelination: Structural and Behavioral Assessments.PloS one · 2016Article
- The regulated expression, intracellular trafficking, and membrane recycling of the P2Y-like receptor GPR17 in Oli-neu oligodendroglial cells.The Journal of biological chemistry · 2013Article
- Identification of Tmem10 as a novel late-stage oligodendrocytes marker for detecting hypomyelination.International journal of biological sciences · 2013Article
- Systematic approaches to central nervous system myelin.Cellular and molecular life sciences : CMLS · 2012Review
- Plasticity of the myelination genomic fabric.Molecular genetics and genomics : MGG · 2012Article
- Identification of VHY/Dusp15 as a regulator of oligodendrocyte differentiation through a systematic genomics approach.PloS one · 2012Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDuring the development of the central nervous system, oligodendrocytes generate large amounts of myelin, a multilayered insulating membrane that ensheathes axons, thereby allowing the fast conduction of the action potential and maintaining axonal integrity. Differentiation of oligodendrocytes to myelin-forming cells requires the downregulation of RhoA GTPase activity.
resultsTo gain insights into the molecular mechanisms of oligodendrocyte differentiation, we performed microarray expression profiling of the oligodendroglial cell line, Oli-neu, treated with the Rho kinase (ROCK) inhibitor, Y-27632 or with conditioned neuronal medium. This resulted in the identification of the transmembrane protein 10 (Tmem10/Opalin), a novel type I transmembrane protein enriched in differentiating oligodendrocytes. In primary cultures, Tmem10 was abundantly expressed in O4-positive oligodendrocytes, but not in oligodendroglial precursor cells, astrocytes, microglia or neurons. In mature oligodendrocytes Tmem10 was enriched in the rims and processes of the cells and was only found to a lesser extent in the membrane sheets.
conclusionTogether, our results demonstrate that Tmem10 is a novel marker for in vitro generated oligodendrocytes.
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