ArticleJournal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research2008
An increase in herpes simplex virus type 1 in the anterior segment of the eye is linked to a deficiency in NK cell infiltration in mice deficient in CXCR3.
Article in Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 35 citations in OpenAlex.
- γδ T17 Cells Regulate the Acute Antiviral Response of NK Cells in HSV-1-Infected Corneas.Investigative ophthalmology & visual science · 2024Article
- The immunobiology of corneal HSV-1 infection and herpetic stromal keratitis.Clinical microbiology reviews · 2024Review
- Initial TK-deficient HSV-1 infection in the lip alters contralateral lip challenge immune dynamics.Scientific reports · 2022Article
- A Regulatory Role of Chemokine Receptor CXCR3 in the Pathogenesis of Chronic Obstructive Pulmonary Disease and Emphysema.Inflammation · 2021Article
- High Frequency of Gamma Interferon-Producing PLZFJournal of virology · 2020Article
- Differential Expression of Immune Checkpoint Molecules on CD8Journal of virology · 2020Article
- Co-infection with Chikungunya virus alters trafficking of pathogenic CD8EMBO molecular medicine · 2018Article
- Optimal CD4 T cell priming after LPS-based adjuvanticity with CD134 costimulation relies on CXCL9 production.Journal of leukocyte biology · 2017Article
- Dynamic change in natural killer cell type in the human ocular mucosa in situ as means of immune evasion by adenovirus infection.Mucosal immunology · 2016Article
- Enhanced resistance of CXCR3 deficient mice to ocular HSV-1 infection is due to control of replication in the brain ependyma.Journal of neuroimmunology · 2014Article
- CXCR3 deficiency enhances tumor progression by promoting macrophage M2 polarization in a murine breast cancer model.Immunology · 2014Article
- Flagellin-induced expression of CXCL10 mediates direct fungal killing and recruitment of NK cells to the cornea in response to Candida albicans infection.European journal of immunology · 2014Article
- HSV-1 targets lymphatic vessels in the eye and draining lymph node of mice leading to edema in the absence of a functional type I interferon response.The American journal of pathology · 2013Article
- Interferon γ-induced intratumoral expression of CXCL9 alters the local distribution of T cells following immunotherapy withOncoimmunology · 2013Article
- Cell mediated innate responses of cattle and swine are diverse during foot-and-mouth disease virus (FMDV) infection: a unique landscape of innate immunity.Immunology letters · 2013Review
- Distinct populations of innate CD8+ T cells revealed in a CXCR3 reporter mouse.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Herpes keratitis.Progress in retinal and eye research · 2013Review
- CD8+ T cells suppress viral replication in the cornea but contribute to VEGF-C-induced lymphatic vessel genesis.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Comparison of the host immune response to herpes simplex virus 1 (HSV-1) and HSV-2 at two different mucosal sites.Journal of virology · 2012Article
- Resident Corneal Cells Communicate with Neutrophils Leading to the Production of IP-10 during the Primary Inflammatory Response to HSV-1 Infection.International journal of inflammation · 2012Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
In response to ocular herpes simplex virus type 1 (HSV-1) infection in mice, a rapid induction or increase in the local expression of chemokines, including CXCL10, is found. The present study investigated the role of the receptor for CXCL10, CXCR3, in the host response to corneal HSV-1 infection. Mice deficient in CXCR3 (CXCR3(-/-)) were found to have an increase in infectious virus in the anterior segment of the eye by day 7 postinfection. Coinciding with the increase, selective chemokines, including CCL2, CCL3, CCL5, CXCL9, and CXCL10, were elevated in the anterior segment of the HSV-1-infected CXCR3(-/-) mice. In contrast, there was a time-dependent reduction in the recruitment of natural killer (NK) cells (NK1.1(+)CD3(-)) into the anterior segment of CXCR3(-/-) mice. A reduction in NK cells residing in the anterior segment of mice following antiasialoGM1 antibody treatment resulted in an increase in infectious virus. No other leukocyte populations infiltrating the tissue were modified in the absence of CXCR3. Collectively, the loss of CXCR3 expression specifically reduces NK cell mobilization into the cornea in response to HSV-1.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.