ArticleAdvances in space research : the official journal of the Committee on Space Research (COSPAR)2007
Potential Role of Oxidative Stress in Mediating the Effect of Altered Gravity on the Developing Rat Cerebellum.
Article in Advances in space research : the official journal of the Committee on Space Research (COSPAR), 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 16 citations in OpenAlex.
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- Characterization of gene expression profiles in the mouse brain after 35 days of spaceflight mission.NPJ microgravity · 2022Article
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- Relationship of plasma MBP and 8-oxo-dG with brain damage in preterm.Open medicine (Warsaw, Poland) · 2022Article
- Spaceflight induces oxidative damage to blood-brain barrier integrity in a mouse model.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020Article
- A load of mice to hypergravity causes AMPKα repression with liver injury, which is overcome by preconditioning loads via Nrf2.Scientific reports · 2015Article
- Article
- Brain development, environment and sex: what can we learn from studying graviperception, gravitransduction and the gravireaction of the developing CNS to altered gravity?Cerebellum (London, England) · 2008Review
- Potential Role of Oxidative Stress in Mediating the Effect of Altered Gravity on the Developing Rat Cerebellum.Advances in space research : the official journal of the Committee on Space Research (COSPAR) · 2007Article
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
We have previously reported that perinatal exposure to hypergravity affects cerebellar structure and motor coordination in rat neonates. In the present study, we explored the hypothesis that exposure to hypergravity results in oxidative stress that may contribute to the decrease in Purkinje cell number and the impairment of motor coordination in hypergravity-exposed rat neonates. To test this hypothesis we compared cerebellar oxidative stress marker 3-nitrotyrosine (3-NT; an index of oxidative protein modification) and 8-hydroxy-2'-deoxyguanosine (8-OH-dG; an index of oxidative DNA damage) between stationary control (SC) and rat neonates exposed to 1.65 G (HG) on a 24-ft centrifuge from gestational day (G) 8 to P21. The levels of 3-NT and 8-OH-dG were determined by specific ELISAs. We also compared the Purkinje cell number (stereorologically) and rotarod performance between the two groups. The levels of 3-NT were increased only in HG females on P6 and on P12 in the cerebellum, and only in HG females on P12 in the extracellabellar tissue. Limited cerebellar data suggests an increase in the levels of 8-OH-dG on P12 only in HG females. In extracerebellar tissue the increase in 8-OH-dG levels was observed in both HG males and HG females except on P6 when it was only observed in HG males. While preliminary, these data suggest that the effect of hypergravity on the developing brain is sex-dependent and may involve oxidative stress. Oxidative stress may, in turn, contribute to the decrease Purkinje cell number and impaired motor behavior observed in hypergravity-exposed rats.
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