Evidence map›Paper›PMID 18437512›Full record

ArticleCancer causes & control : CCC2008

Physical activity, sedentary behavior, and the risk of colon and rectal cancer in the NIH-AARP Diet and Health Study.

Regan A Howard, D Michal Freedman, Yikyung Park, Albert Hollenbeck, Arthur Schatzkin, Michael F Leitzmann

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer causes & control : CCC, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 91 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
91citing papers in PubMed, 8 pooled it
13.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

91 citing papers in PubMed, 8 syntheses or guidelines pooled it, 235 citations in OpenAlex.

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  10. Modelling the potential health and economic benefits of reducing population sitting time in Australia.The international journal of behavioral nutrition and physical activity · 2022
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31 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Regan A HowardDivision of Cancer Epidemiology and Genetics, Radiation Epidemiology Branch, National Cancer Institute, NIH, DHHS, Bethesda, MD, 20892, USA. reganho@mail.nih.gov
D Michal Freedman
Yikyung Park
Albert Hollenbeck
Arthur Schatzkin
Michael F Leitzmann
Division of Cancer Epidemiology and GeneticsAARP · USNational Cancer Institute · USUnited States Department of Health and Human Services · US

Funding

Prospective Studies of Diet and Cancer in the AARP CohortZ01CP010196 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI SCHATZKIN, ARTHUR · 2008 to 2008
$1.5M
Intramural NIH HHS Z01 CP010196
6 · The paper itself

Abstract

objectiveIn order to prospectively investigate physical activity at varying intensities and sedentary behavior in relation to colorectal cancer.

methodsWe considered 488,720 participants of the NIH-AARP Diet and Health Study who were aged 50-71 years at baseline in 1995-1996. Through 31 December, 2003, we identified 3,240 and 1,482 colorectal cancers among men and women, respectively. We estimated multivariable relative risks (RR) and 95% confidence intervals (CI) of colorectal cancer using Cox regression.

resultsEngaging in exercise/sports five or more times per week compared to never or rarely exercising was associated with a reduced risk of colon cancer among men (p = 0.001; RR = 0.79, 95% CI = 0.68-0.91) and a suggestive decrease in risk among women (p = 0.376; RR = 0.85, 95% CI = 0.70-1.04). Engaging in exercise/sports was also associated with a decreased risk of rectal cancer in men (P = 0.074; RR comparing extreme categories = 0.76, 95% CI = 0.61-0.94). In men, we observed inverse relations of both low intensity (p = 0.017; RR = 0.81, 95% CI = 0.65-1.00 for > or =7 h/week) and moderate to vigorous intensity activity (p = 0.037; RR = 0.82, 95% CI = 0.67-0.99 for > or =7 h/week) to colon cancer risk. In contrast, sedentary behavior (time spent watching television/videos) was positively associated with colon cancer (p < 0.001; RR = 1.61, 95% CI = 1.14-2.27 for > or =9 h/day) among men. Similar, but less pronounced relations were observed in women.

conclusionEngaging in physical activity of any intensity is associated with reductions in colon and rectal cancer risk. Conversely, time spent sedentary is associated with increased colon cancer risk.

Indexed as

ExerciseAgedColonic NeoplasmsFemaleFollow-Up StudiesHealth BehaviorHealth SurveysHumansMaleMiddle AgedOdds RatioRectal Neoplasms

Identifiers

PMID18437512
PMCPMC2574900
OpenAlexW2081790335

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.