ArticleMolecular imaging and biology
Genome-free viral capsids as carriers for positron emission tomography radiolabels.
Article in Molecular imaging and biology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The trial behind it
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Who cites it
24 citing papers in PubMed, 56 citations in OpenAlex.
- Virus-like nanoparticles as a theranostic platform for cancer.Frontiers in bioengineering and biotechnology · 2022Review
- Self-assembled Viral Nanoparticles as Targeted Anticancer Vehicles.Biotechnology and bioprocess engineering : BBE · 2021Review
- Virus-like particles: Next-generation nanoparticles for targeted therapeutic delivery.Bioengineering & translational medicine · 2017Review
- Engineering protein nanocages as carriers for biomedical applications.NPG Asia materials · 2017Review
- Design of virus-based nanomaterials for medicine, biotechnology, and energy.Chemical Society reviews · 2016Review
- Virus-Based Nanoparticles as Versatile Nanomachines.Annual review of virology · 2015Review
- Polymeric Nanostructures for Imaging and Therapy.Chemical reviews · 2015Review
- Design rules for nanomedical engineering: from physical virology to the applications of virus-based materials in medicine.Journal of biological physics · 2013Review
- Controlled integration of gold nanoparticles and organic fluorophores using synthetically modified MS2 viral capsids.Journal of the American Chemical Society · 2013Article
- Increased tumor homing and tissue penetration of the filamentous plant viral nanoparticle Potato virus X.Molecular pharmaceutics · 2013Article
- Formylbenzene diazonium hexafluorophosphate reagent for tyrosine-selective modification of proteins and the introduction of a bioorthogonal aldehyde.Bioconjugate chemistry · 2012Article
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- Applications of viral nanoparticles in medicine.Current opinion in biotechnology · 2011Review
- Using synthetically modified proteins to make new materials.Accounts of chemical research · 2011Article
- Bio-inspired, bioengineered and biomimetic drug delivery carriers.Nature reviews. Drug discovery · 2011Review
- Protein cage nanoparticles bearing the LyP-1 peptide for enhanced imaging of macrophage-rich vascular lesions.ACS nano · 2011Article
- The art of engineering viral nanoparticles.Molecular pharmaceutics · 2011Review
- Immobilization and one-dimensional arrangement of virus capsids with nanoscale precision using DNA origami.Nano letters · 2010Article
- Modified natural nanoparticles as contrast agents for medical imaging.Advanced drug delivery reviews · 2010Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeWe have developed a modular synthetic strategy to append imaging agents to a viral capsid. PROCEDURES: The hollow protein shell of bacteriophage MS2 (mtMS2) was labeled on its inside surface with [18F]fluorobenzaldehyde through a multistep bioconjugation strategy. An aldehyde functional group was first attached to interior tyrosine residues through a diazonium coupling reaction. The aldehyde was further elaborated to an alkoxyamine functional group, which was then condensed with n.c.a. [18F]fluorobenzaldehyde. Biodistribution of the radioactive MS2 conjugates was subsequently evaluated in Sprague-Dawley rats.
resultsRelative to fluorobenzaldehyde, fluorine-18-labeled MS2 exhibited prolonged blood circulation time and a significantly altered excretion profile. It was also observed that additional small molecule cargo installed inside the capsids did not alter the biodistribution.
conclusionsThese studies provide further insight into the pharmacokinetic behavior of nanomaterials and serve as a platform for the future development of targeted imaging and therapeutic agents based on mtMS2.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.