Trial reportEuropean archives of psychiatry and clinical neuroscience2008
Eye movement deficits in schizophrenia: investigation of a genetically homogenous Icelandic sample.
Trial report in European archives of psychiatry and clinical neuroscience, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 29 citations in OpenAlex.
- Effects of nicotine on smooth pursuit eye movements in healthy non-smokers.Psychopharmacology · 2019Trial
- Effects of ketamine on brain function during smooth pursuit eye movements.Human brain mapping · 2016Trial
- Fixation Task: A Simple Eye Movement Task Reveals an Impairment in Schizophrenia.Schizophrenia bulletin · 2026Article
- Eye movement indices as predictors of conversion to psychosis in individuals at clinical high risk.European archives of psychiatry and clinical neuroscience · 2023Article
- Eye movements in patients in early psychosis with and without a history of cannabis use.NPJ schizophrenia · 2021Article
- To look or not to look? Reward, selection history, and oculomotor guidance.Journal of neurophysiology · 2018Article
- Neural mechanisms of smooth pursuit eye movements in schizotypy.Human brain mapping · 2015Article
- Enhanced top-down control during pursuit eye tracking in schizophrenia.European archives of psychiatry and clinical neuroscience · 2013Article
- Antisaccade performance in schizophrenia patients, their first-degree biological relatives, and community comparison subjects: data from the COGS study.Psychophysiology · 2010Article
- Neuregulin-1 genotypes and eye movements in schizophrenia.European archives of psychiatry and clinical neuroscience · 2010Article
- Catechol-O-methyltransferase Val 158 Met polymorphism and antisaccade eye movements in schizophrenia.Schizophrenia bulletin · 2010Article
- Exploratory eye movement dysfunction as a discriminator for schizophrenia : a large sample study using a newly developed digital computerized system.European archives of psychiatry and clinical neuroscience · 2009Article
- Markers of vulnerability in schizophrenia.Journal of medicine and lifeReview
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDeficits in antisaccade (AS) and smooth pursuit eye movements (SPEM) are promising endophenotypes in genetic studies of schizophrenia. The Icelandic population lends itself ideally to genetic studies due to its ethnic homogeneity and well-documented genealogy. The primary aim of this study was to assess AS and SPEM performance in a large Icelandic sample. Additional aims were to investigate the relationship between AS and SPEM task performance and to assess internal consistency, within-session performance changes and effects of SPEM target velocity on performance.
methodPatients with schizophrenia (N = 118) and healthy controls (N = 109) matched for age and gender underwent infrared oculographic assessment of AS and SPEM (at target velocities of 12 degrees , 24 degrees and 36 degrees /s).
resultsOn the AS task patients displayed significantly more reflexive errors, longer latency, increased intra-individual latency variability, and reduced amplitude gain compared to controls. On the SPEM task, patients had significantly lower velocity gain and more frequent saccades during pursuit at all velocities, but group differences in velocity gain increased with increasing target velocity. Internal consistency of performance was high for all variables in both groups (Cronbach's alpha >0.77 for AS and >0.85 for SPEM) except for AS spatial error in patients (alpha = 0.38). A moderate association was found between AS and SPEM performance. By and large, patients and controls showed similar patterns of systematic within-session performance changes.
conclusionsOur findings confirm the existence of robust eye movement deficits in schizophrenia in a large sample. These measures may be studied as endophenotypes in future studies of potential schizophrenia risk genotypes in the genetically homogenous Icelandic population.
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