Evidence map›Paper›PMID 18437250›Full record

ArticlePhysica D. Nonlinear phenomena2007

Nested Canalyzing, Unate Cascade, and Polynomial Functions.

Abdul Salam Jarrah, Blessilda Raposa, Reinhard Laubenbacher

Abstract read
In one paragraph

Article in Physica D. Nonlinear phenomena, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. BioLogical: a universal analysis framework for biosystem logical dynamics.Computational and structural biotechnology journal · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Attractor detection and enumeration algorithms for Boolean networks.Computational and structural biotechnology journal · 2022
    Review
  7. Molecular network control through boolean canalization.EURASIP journal on bioinformatics & systems biology · 2015
    Article
  8. Robustness, canalyzing functions and systems design.Theory in biosciences = Theorie in den Biowissenschaften · 2014
    Article
  9. Properties of Boolean networks and methods for their tests.EURASIP journal on bioinformatics & systems biology · 2013
    Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Abdul Salam JarrahVirginia Bioinformatics Institute (0477), Virginia Tech, Blacksburg, VA 24061, USA.
Blessilda Raposa
Reinhard Laubenbacher

Funding

Mathematical Modeling - Biochemical Networks in YeastR01GM068947 · NIGMS · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI LAUBENBACHER, REINHARD · 2003 to 2006
$1.1M
NIGMS NIH HHS R01 GM068947
6 · The paper itself

Abstract

This paper focuses on the study of certain classes of Boolean functions that have appeared in several different contexts. Nested canalyzing functions have been studied recently in the context of Boolean network models of gene regulatory networks. In the same context, polynomial functions over finite fields have been used to develop network inference methods for gene regulatory networks. Finally, unate cascade functions have been studied in the design of logic circuits and binary decision diagrams. This paper shows that the class of nested canalyzing functions is equal to that of unate cascade functions. Furthermore, it provides a description of nested canalyzing functions as a certain type of Boolean polynomial function. Using the polynomial framework one can show that the class of nested canalyzing functions, or, equivalently, the class of unate cascade functions, forms an algebraic variety which makes their analysis amenable to the use of techniques from algebraic geometry and computational algebra. As a corollary of the functional equivalence derived here, a formula in the literature for the number of unate cascade functions provides such a formula for the number of nested canalyzing functions.

Identifiers

PMID18437250
PMCPMC2330334

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.