ArticlePLoS genetics2008
Identification of CIITA regulated genetic module dedicated for antigen presentation.
Article in PLoS genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 45 citations in OpenAlex.
- A Ménage à trois: NLRC5, immunity, and metabolism.Frontiers in immunology · 2024Review
- BCG-Induced Tumor Immunity Requires Tumor-Intrinsic CIITA Independent of MHC-II.Cancer immunology research · 2022Article
- Article
- NLRC5 promotes transcription ofiScience · 2021Article
- The MHC Class II Transactivator CIITA: Not (Quite) the Odd-One-Out Anymore among NLR Proteins.International journal of molecular sciences · 2021Review
- Identification of Two Novel Candidate Genetic Variants Associated With the Responsiveness to Influenza Vaccination.Frontiers in immunology · 2021Article
- A caspase-2-RFXANK interaction and its implication for MHC class II expression.Cell death & disease · 2018Article
- Revisiting the specificity of the MHC class II transactivator CIITA in classical murine dendritic cells in vivo.European journal of immunology · 2017Article
- Btn2a2, a T cell immunomodulatory molecule coregulated with MHC class II genes.The Journal of experimental medicine · 2016Article
- Genome-wide CIITA-binding profile identifies sequence preferences that dictate function versus recruitment.Nucleic acids research · 2015Article
- NLRC5 exclusively transactivates MHC class I and related genes through a distinctive SXY module.PLoS genetics · 2015Article
- Extensive remodeling of DC function by rapid maturation-induced transcriptional silencing.Nucleic acids research · 2014Article
- Genomic mapping of the MHC transactivator CIITA using an integrated ChIP-seq and genetical genomics approach.Genome biology · 2014Article
- HLA-dependent tumour development: a role for tumour associate macrophages?Journal of translational medicine · 2013Review
- NLRC5: a key regulator of MHC class I-dependent immune responses.Nature reviews. Immunology · 2012Review
- Zinc finger transcription factor zDC is a negative regulator required to prevent activation of classical dendritic cells in the steady state.The Journal of experimental medicine · 2012Article
- CIITA promoter I CARD-deficient mice express functional MHC class II genes in myeloid and lymphoid compartments.Genes and immunity · 2012Article
- Article
- Operons.Cellular and molecular life sciences : CMLS · 2009Review
- Nucleosome eviction from MHC class II promoters controls positioning of the transcription start site.Nucleic acids research · 2009Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The class II trans-activator CIITA is a transcriptional co-activator required for the expression of Major Histocompatibility Complex (MHC) genes. Although the latter function is well established, the global target-gene specificity of CIITA had not been defined. We therefore generated a comprehensive list of its target genes by performing genome-wide scans employing four different approaches designed to identify promoters that are occupied by CIITA in two key antigen presenting cells, B cells and dendritic cells. Surprisingly, in addition to MHC genes, only nine new targets were identified and validated by extensive functional and expression analysis. Seven of these genes are known or likely to function in processes contributing to MHC-mediated antigen presentation. The remaining two are of unknown function. CIITA is thus uniquely dedicated for genes implicated in antigen presentation. The finding that CIITA regulates such a highly focused gene expression module sets it apart from all other transcription factors, for which large-scale binding-site mapping has indicated that they exert pleiotropic functions and regulate large numbers of genes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.