Evidence map›Paper›PMID 18436917›Full record

ArticleBMJ (Clinical research ed.)2008

Uptake of first two doses of human papillomavirus vaccine by adolescent schoolgirls in Manchester: prospective cohort study.

Loretta Brabin, Stephen A Roberts, Rebecca Stretch, David Baxter, Gloria Chambers, Henry Kitchener, Rosemary McCann

Abstract read
In one paragraph

Article in BMJ (Clinical research ed.), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 93 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
93citing papers in PubMed, 8 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

93 citing papers in PubMed, 8 syntheses or guidelines pooled it.

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  11. What do parents of school-aged children want to know about HPV vaccination in Canada? Results of an online survey on Facebook.Canada communicable disease report = Releve des maladies transmissibles au Canada · 2026
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33 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Loretta BrabinAcademic Unit of Obstetrics and Gynaecology, St Mary's Hospital, University of Manchester, Manchester M13 OJH. loretta.brabin@manchester.ac.uk
Stephen A Roberts
Rebecca Stretch
David Baxter
Gloria Chambers
Henry Kitchener
Rosemary McCann

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo assess the feasibility and acceptability of delivering a human papillomavirus (HPV) vaccine to adolescent girls.

designProspective cohort study.

setting36 secondary schools in two primary care trusts in Greater Manchester, United Kingdom.

participants2817 schoolgirls in year 8 (12 and 13 year olds).

interventionDelivery of the bivalent vaccine at 0, 1, and 6 months over one school year.

main outcome measuresVaccine uptake for doses 1 and 2 of a three dose schedule.

resultsVaccine uptake was 70.6% (1989/2817) for the first dose and 68.5% (1930/2817) for the second dose. Uptake was significantly lower in schools with a higher proportion of ethnic minority girls (P<0.001 for trend) or higher proportion of girls entitled to free school meals (P=0.029 for trend). The main reason for parents' refusal of vaccination was insufficient information about the vaccine and its long term safety. Maintaining the vaccine schedule was challenging as 16.3% (dose 1) and 23.6% (dose 2) of girls missed their vaccination day and had to be offered alternative appointments. No serious adverse events were reported.

conclusionDelivery of the first two doses of HPV vaccine to adolescent schoolgirls is encouraging, but the success of the vaccination programme depends on high coverage for the third dose.

Indexed as

AdolescentCohort StudiesDelivery of Health CareEnglandFemaleHumansPapillomavirus InfectionsPapillomavirus VaccinesPatient Acceptance of Health CareProspective StudiesSchool Health ServicesVaccinationPapillomavirus Vaccines

Identifiers

PMID18436917
PMCPMC2375997

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.